Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

803
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
803
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

1.7K
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
1.7K
Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

1.6K
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
1.6K
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

758
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
758
Accessory Structures of the Skin: Sebaceous Glands01:21

Accessory Structures of the Skin: Sebaceous Glands

4.1K
A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
4.1K
The Extracellular Matrix01:42

The Extracellular Matrix

88.5K
Overview
88.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Universal Base-Catalyzed Aza-Michael Addition: A General Platform for Transforming Polyurethanes into High-Performance Injectable Thermogels.

Journal of the American Chemical Society·2026
Same author

Visible Light Photo-Cross-Linked Thermogel─A Single-Component Hybrid Supramolecular-Covalent Hydrogel for Sustained Drug Release.

ACS applied materials & interfaces·2026
Same author

Current research and future potential of thermogels for sustained drug delivery.

Expert opinion on drug delivery·2025
Same author

Dynamic Covalent Hydrogels for Wound Healing.

Annual review of chemical and biomolecular engineering·2025
Same author

Modular Synthetic Platform to Tailor Therapeutic-Specific Delivery in Injectable Hydrogels.

ACS applied materials & interfaces·2024
Same author

Osteolipoma of the hand: A case report.

International journal of surgery case reports·2024

Related Experiment Video

Updated: Jan 26, 2026

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

8.8K

A Thixotropic Polyglycerol Sebacate-Based Supramolecular Hydrogel as an Injectable Drug Delivery Matrix.

Hongye Ye1, Cally Owh2, Shan Jiang3,4

  • 1Institute of Materials Research and Engineering (IMRE), A*STAR (Agency for Science, Technology and Research), 2 Fusionopolis Way, Innovis, #08-03, Singapore 138634, Singapore. yehy@imre.a-star.edu.sg.

Polymers
|April 14, 2019
PubMed
Summary

A novel self-healing hydrogel made from polyglycerol sebacate-polyethylene glycol methyl ether methacrylate (PGS-PEGMEMA)/α-Cyclodextrin (αCD) can be injected as a liquid and reforms into a gel. This biocompatible and tunable material shows potential for in vivo applications and controlled drug delivery.

Keywords:
injectable hydrogelpolyglycerol sebacateself-healingshear-thinningsupramolecular

More Related Videos

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart
10:28

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart

Published on: June 7, 2015

17.9K
Preparation of Chitosan-based Injectable Hydrogels and Its Application in 3D Cell Culture
08:05

Preparation of Chitosan-based Injectable Hydrogels and Its Application in 3D Cell Culture

Published on: September 29, 2017

20.0K

Related Experiment Videos

Last Updated: Jan 26, 2026

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

8.8K
An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart
10:28

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart

Published on: June 7, 2015

17.9K
Preparation of Chitosan-based Injectable Hydrogels and Its Application in 3D Cell Culture
08:05

Preparation of Chitosan-based Injectable Hydrogels and Its Application in 3D Cell Culture

Published on: September 29, 2017

20.0K

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Drug Delivery Systems

Background:

  • Developing injectable hydrogels with tunable mechanical properties and self-healing capabilities is crucial for tissue engineering and drug delivery.
  • Polyglycerol sebacate-polyethylene glycol methyl ether methacrylate (PGS-PEGMEMA) and α-Cyclodextrin (αCD) offer a promising combination for creating advanced hydrogel systems.

Purpose of the Study:

  • To develop and characterize a novel self-healing hydrogel based on PGS-PEGMEMA/αCD for potential in vivo applications.
  • To evaluate the hydrogel's injectability, biocompatibility, biodegradability, mechanical properties, and drug release kinetics.
  • To establish a predictive model for drug release based on hydrogel composition and erosion mechanisms.

Main Methods:

  • Synthesis and characterization of the PGS-PEGMEMA/αCD hydrogel.
  • Assessment of injectability, self-healing properties, and mechanical moduli (storage and loss moduli).
  • In vitro biocompatibility and biodegradability studies.
  • In vitro drug (doxorubicin) release studies and kinetic modeling (First Order and Hopfenberg equations).

Main Results:

  • The PGS-PEGMEMA/αCD hydrogel exhibited excellent self-healing properties, transitioning from gel to liquid upon shearing and rapidly recovering its gel state.
  • The hydrogel's mechanical properties were tunable by adjusting αCD concentration, matching the moduli of soft tissues.
  • In vitro studies confirmed the hydrogel's biocompatibility, biodegradability, linear mass erosion, and biphasic doxorubicin release (diffusion and erosion phases).

Conclusions:

  • The developed PGS-PEGMEMA/αCD hydrogel is a promising injectable, self-healing, and mechanically tunable biomaterial suitable for in vivo applications.
  • The established drug release model provides a framework for predicting and controlling drug delivery rates for various therapeutic agents.
  • This hydrogel platform holds significant potential for advancing regenerative medicine and localized drug delivery strategies.