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Related Concept Videos

Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

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Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
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Modified-Release Drug Delivery Systems: Overview01:19

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Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
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Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
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Modified-Release Drug Delivery Systems: Site-Targeted01:24

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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices01:28

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

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Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...
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Updated: Apr 13, 2026

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart
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Modular Synthetic Platform to Tailor Therapeutic-Specific Delivery in Injectable Hydrogels.

Joey Hui Min Wong1, Belynn Sim1,2, Cally Owh1,3

  • 1Institute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), 2 Fusionopolis Way, #08-03 Innovis, Singapore 138634, Republic of Singapore.

ACS Applied Materials & Interfaces
|November 19, 2024
PubMed
Summary

Researchers developed a new platform for creating customizable injectable thermogels for drug delivery. These functionalized polyurethane thermogels offer tunable properties for precise, sustained drug release over extended periods.

Keywords:
Click reactionDrug-specific formulationFunctionalized polyurethaneInjectable hydrogelSustained drug releaseThiol−eneTunable drug release

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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Drug Delivery Systems

Background:

  • Injectable thermoresponsive hydrogels (thermogels) are valuable for in situ forming implants in drug delivery and regenerative medicine.
  • Their sol-to-gel transition at body temperature influences drug release kinetics and cell fate.
  • Current synthetic methods often restrict matrix-agent interactions, limiting therapeutic potential.

Purpose of the Study:

  • To introduce a modular synthetic platform for creating functionalized polyurethane thermogels.
  • To enable customization of gelation properties and intermolecular interactions for tailored drug delivery.
  • To investigate the impact of tunable thermogel properties on drug release profiles.

Main Methods:

  • Developed a modular synthetic platform for polyurethane thermogels.
  • Functionalized thermogels to control stiffness, ionic interactions, hydrophobicity, and hydrogen bonding.
  • Evaluated drug release kinetics for low and high molecular weight analogs using these tunable thermogels.

Main Results:

  • Achieved sustained and controlled drug release ranging from days to over 6 months.
  • Demonstrated varied release profiles (monophasic, biphasic, triphasic) based on thermogel-agent compatibility.
  • Established design rules for developing drug-specific formulations with precise release modulation.

Conclusions:

  • The developed platform allows for customizable injectable drug depots with tunable properties.
  • This strategy facilitates precise, sustained, and modulated drug release tailored to therapeutic needs.
  • Lays groundwork for multi-stimuli-responsive thermogels with enhanced bioactivity for advanced therapeutic systems.