Bacillus Calmette-Guerin Immunotherapy for Recurrent Multiple Warts: An Open-Label Uncontrolled Study
Avtar Kishan Jaisinghani1, Vivek Kumar Dey2, M S Suresh2
1Department of Dermatology, People's College of Medical Sciences and Research Centre, Bhopal, Madhya Pradesh, India.
Indian Journal of Dermatology
|April 16, 2019
Summary
Intralesional bacillus Calmette-Guerin (BCG) vaccine immunotherapy effectively treated recurrent multiple warts, with 73.53% achieving complete clearance. This safe and promising treatment prevented recurrence in patients who responded fully.
Area of Science:
- Dermatology
- Immunotherapy
- Vaccinology
Background:
- Cutaneous warts pose treatment challenges due to recurrence and multiplicity.
- Intralesional immunotherapy is increasingly used for recurrent warts, showing efficacy in clearing distant lesions and preventing recurrence.
Purpose of the Study:
- To evaluate the efficacy and safety of intralesional bacillus Calmette-Guerin (BCG) vaccine immunotherapy.
- To assess BCG vaccine's effectiveness in treating recurrent multiple extragenital warts.
Main Methods:
- 40 adult patients with multiple recurrent warts received intralesional BCG vaccine injections.
- Injections were administered into the largest wart at 3-week intervals for up to three sessions.
- Patients were monitored for 3 months post-treatment to assess clearance and recurrence.
Main Results:
- Complete lesion clearance was achieved in 73.53% of patients, with partial clearance in 23.53%.
- 75% of patients with distant warts showed a complete response.
- Mild side effects including injection site pain, itching, erythema, and flu-like symptoms were reported.
Conclusions:
- Intralesional BCG immunotherapy is a safe and effective treatment for recurrent multiple warts.
- BCG immunotherapy demonstrates potential for clearing warts and preventing their recurrence.
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