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Updated: Jan 26, 2026

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Published on: September 16, 2022
Urine-Based Liquid Biopsy for Nonurological Cancers
Surbhi Jain1, Selena Y Lin1, Wei Song1
11 JBS Science, Inc., Doylestown, Pennsylvania.
Urine liquid biopsy shows promise for nonurological cancer detection and monitoring. This noninvasive method offers a patient-friendly alternative to blood tests for screening, early detection, and tracking treatment effectiveness.
Area of Science:
- Oncology
- Genetics
- Biomarkers
Background:
- Circulating cell-free DNA (cfDNA) analysis is crucial for cancer genetics.
- Liquid biopsy, typically blood-based, detects circulating tumor DNA (ctDNA).
- Urine presents a promising, noninvasive alternative source for ctDNA detection.
Purpose of the Study:
- To review the clinical utility of urine for genetic liquid biopsy.
- Focus on nonurological cancers.
Main Methods:
- Review of recent studies on urine-based liquid biopsies.
- Analysis of ctDNA detection in urine for nonurological cancers.
Main Results:
- Urine liquid biopsies demonstrate value in nonurological cancer screening and early detection.
- Urine analysis aids in monitoring cancer recurrence, metastasis, and therapeutic efficacy.
- Studies show urine is a viable source for ctDNA detection.
Conclusions:
- Urine-based liquid biopsy is a developing field with significant potential.
- Its noninvasive nature makes it a patient-friendly alternative to blood biopsies.
- Further development is warranted to fully realize its clinical utility for nonurological cancers.
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