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Updated: Jan 26, 2026
09:44
Development, Characterization, and Evaluation of CAGE-based Ionic Liquid Systems for Transdermal Delivery
Published on: September 26, 2025
475
Carboxymethyl cellulose-based oral delivery systems.
Siamak Javanbakht1, Ahmad Shaabani1
1Faculty of Chemistry, Shahid Beheshti University, G. C., P. O. Box 19396-4716, Tehran, Iran.
International Journal of Biological Macromolecules
|April 16, 2019
Summary
Carboxymethyl cellulose offers unique hydrophilic properties for oral drug delivery systems. Its carboxylate groups enable in situ gellation, bioadhesion, and controlled release, with potential for further enhancement via chemical modification.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Oral drug administration is preferred for patient comfort and cost-effectiveness.
- Carboxymethyl cellulose (CMC) is increasingly utilized in oral delivery systems.
- Unlike other polysaccharides, CMC exhibits hydrophilicity due to its carboxylate groups.
Purpose of the Study:
- To review the advantages of carboxymethyl cellulose for oral drug delivery.
- To highlight the unique properties of CMC relevant to pharmaceutical formulations.
Main Methods:
- Literature review of carboxymethyl cellulose applications in oral delivery.
- Analysis of CMC's physicochemical properties and their impact on drug release.
Main Results:
- CMC's carboxylate groups confer properties like in situ gellation and bioadhesion.
- These properties facilitate controlled drug release and responsiveness to environmental stimuli.
- Chemical modifications can further optimize CMC's performance in drug delivery.
Conclusions:
- Carboxymethyl cellulose presents significant advantages as a versatile excipient for oral drug delivery systems.
- Its inherent properties and modifiability make it a promising candidate for advanced pharmaceutical formulations.
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