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Generation of Alginate Microspheres for Biomedical Applications

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Published on: August 12, 2012

Injectable Hydrogels Based on Pluronic/Water Systems Filled with Alginate Microparticles for Biomedical Applications.

M T Cidade¹, D J Ramos², J Santos³

¹i3N/CENIMAT, Department of Materials Science, Faculty of Sciences and Technology, Universidade, NOVA de Lisboa, Campus de Caparica, 2829-516 Caparica, Portugal. mtc@fct.unl.pt.

Materials (Basel, Switzerland)

|April 17, 2019

Summary

This summary is machine-generated.

A novel thermoresponsive hydrogel composite system was developed for controlled drug delivery. This system, using Pluronic F127 hydrogel and alginate microparticles, demonstrated significantly slower drug release, indicating potential for advanced delivery applications.

Keywords:

Pluronic/water systems alginate microparticles composites dual cargo delivery systems injectable gels rheology

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Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Published on: October 26, 2016

Area of Science:

Biomaterials Science
Drug Delivery Systems
Polymer Chemistry

Background:

Thermoresponsive hydrogels offer potential for injectable drug delivery systems.
Composite systems can modulate drug release kinetics.
Pluronic F127 hydrogels exhibit temperature-dependent phase transitions.

Purpose of the Study:

To develop and characterize a composite hydrogel system for drug delivery.
To evaluate the drug release profile of the composite system compared to a simple hydrogel.
To assess the potential of the system for dual cargo release applications.

Main Methods:

Formulation of a composite system using Pluronic F127 hydrogel and alginate microparticles.
Rheological characterization to determine optimal Pluronic F127 and alginate concentrations.
Drug release studies using Methylene Blue (MB) as a model drug.

Main Results:

Optimal concentrations determined for Pluronic F127 (15.5 wt%) and alginate microparticles (5 and 10 wt%).
The composite system exhibited a 10-fold slower Methylene Blue release compared to Pluronic hydrogel alone.
Successful development of a thermoresponsive composite hydrogel for controlled release.

Conclusions:

The developed Pluronic F127/alginate microparticle composite hydrogel is a promising platform for controlled drug delivery.
The system's tunable release kinetics suggest suitability for dual cargo delivery.
Further research could explore its applications in tissue engineering and advanced therapeutics.