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Published on: February 11, 2016
Iridium-Catalyzed Distal Hydroboration of Aliphatic Internal Alkenes
Guangzhu Wang1,2, Xinyi Liang3, Lili Chen2
1College of Chemistry and Molecular Engineering, Henan Institute of Advanced Technology, Zhengzhou University, Zhengzhou, 450001, China.
Abstract:
The regioselective hydroboration of aliphatic internal alkenes remains a great challenge. Reported herein is an iridium-catalyzed hydroboration of aliphatic internal alkenes, providing distal-borylated products in good to excellent yields with high regioselectivity (up to 99:1). We also demonstrate that the C-B bond of the distal-borylated product can be readily converted into other functional groups. DFT calculations indicate that the reaction proceeds through an unexpected IrIII /IrV cycle.
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