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Optical Multiplexed Bioassays for Improved Biomedical Diagnostics.

Yong Fan1, Shangfeng Wang1, Fan Zhang1

  • 1Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, State Key Laboratory of Molecular Engineering of Polymers and iChem, Fudan University, Shanghai, 200433, China.

Angewandte Chemie (International Ed. in English)
|April 18, 2019
PubMed
Summary
This summary is machine-generated.

Multiplexed bioassays offer superior accuracy for disease diagnosis by analyzing multiple biomarkers simultaneously. This review highlights optical techniques like fluorescence and SERS for advanced biomedical diagnostics.

Keywords:
bioimagingdiagnosticsencodingmultiplexingoptical bioassays

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Area of Science:

  • Biomedical Diagnostics
  • Analytical Chemistry
  • Optical Biosensing

Background:

  • Single-marker detection methods lack accuracy due to disease complexity involving multiple biomolecules.
  • High-throughput multiplexed bioassays are crucial for advancing biomedical research and clinical applications.

Purpose of the Study:

  • To review recent advancements in optical multiplexed analytical techniques for enhanced biomedical diagnostics.
  • To highlight the application of fluorescence and surface-enhanced Raman scattering (SERS) in multiplexed bioanalysis.

Main Methods:

  • Focus on optical multiplexed analytical techniques, specifically fluorescence and SERS.
  • Summarize recent contributions in multiplexed biosensing, cellular tracking, and in vivo bioimaging.

Main Results:

  • Optical techniques like fluorescence and SERS enable simultaneous detection of multiple disease markers.
  • Multiplexed strategies show promise in areas from analyte detection to in vivo imaging.

Conclusions:

  • Optical multiplexed bioanalysis significantly improves diagnostic accuracy and research capabilities.
  • Future opportunities lie in addressing challenges for more sophisticated multiplexed bioassays.