Related Experiment Video
Updated: Jan 26, 2026

Intra-Cardiac Injection of Human Prostate Cancer Cells to Create a Bone Metastasis Xenograft Mouse Model
Published on: November 4, 2022
[Bone effects of bisphosphonates and denosumab treatments in breast or prostate cancer]
1Service des maladies osseuses, Département de médecine, HUG et Faculté de médecine, 1211 Genève 14.
Abstract:
Two types of bone diseases can be observed in patients with breast or prostate cancer: fragility fractures related to osteoporosis, and skeletal related events (SRE) complicating bone metastases. Aromatase inhibitors, ovarian function suppression and tamoxifen use in pre-menopausal women, and androgen deprivation therapy, induce a decrease of bone mineral density and an increase of the incidence of fractures, which can be prevented by inhibitors of bone resorption at low doses. In addition, adjuvant bisphosphonates may be associated with benefits on disease free survival, especially regarding bone recurrences, in postmenopausal women with non-metastatic breast cancer. In the presence of bone metastases, inhibitors of bone resorption at higher doses and frequencies prevent SRE.
More Related Videos
Related Concept Videos
Treatment Resistant Cancers
Buffer Effectiveness
The buffer capacity is the amount of acid or base that can be added to a given volume...
Framing Effects
Biological Effects of Radiation
Spongy Bone
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
Compact Bone
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...

