Related Experiment Video
Updated: Jan 26, 2026

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
Published on: April 11, 2018
Study of Quality of Life in Patients with Soft Tissue Reconstruction Following Mandibulectomy
Kanchan P Dholam1, Karthik M Sadashiva2, Sandeep Gurav1
11Department of Dental and Prosthetic Surgery, Tata Memorial Hospital, HBNI, Room No 217, Homi Bhabha Block, Dr. E Borges Marg, Parel, Mumbai, 400012 India.
Purpose:
To study the effect of mandibulectomy with soft tissue reconstruction on quality of life (QOL) and functions of speech and swallowing.
Methodology:
Quality of life of 66 patients was evaluated by using EORTC QLQ-C30 and EORTC-HN35 questionnaires. Speech was evaluated objectively by Dr. Speech software version 4 and subjectively by a single speech therapist along with swallowing. Patients were evaluated preoperatively and 6 months after treatment.
Results:
Out of 66 patients, 57 followed up postoperatively. Comparison of preoperative and postoperative QOL, speech, and swallowing was done by using paired 't' test or Wilcoxon signed-rank test as per distribution. When evaluated by EORTC QLQ-C30 and EORTC-HN35, statistically significant difference was found in the domains of physical function, fatigue, nausea-vomiting, dyspnea and appetite loss, pain, nutrition, swallowing speech and dry mouth. Significant difference was found in speech (maximum intensity) and most of the domains of swallowing.
Conclusion:
In EORTC QLQ-C30 questionnaire, all functional scales showed deterioration with maximum in physical function. Symptom scales showed worsening but significant improvement was found in pain when evaluated by EORTC-HN35. However, the global health status/QL was found to be improved marginally.
Related Concept Videos
Half-life of a Reaction
Characteristics of Life
The Angiosperm Life Cycle
The Tree of Life - Bacteria, Archaea, Eukaryotes
Life Histories
Three-Domain System of Life

