Related Experiment Video
Updated: Jan 26, 2026

Quantitative Measurement of Intrathecally Synthesized Proteins in Mice
Published on: November 29, 2019
Total Syntheses of Pleiocarpamine, Normavacurine, and C-Mavacurine
Keigo Sato1, Noriyuki Kogure1, Mariko Kitajima1
1Graduate School of Pharmaceutical Sciences , Chiba University , 1-8-1 Inohana, Chuo-ku , Chiba 260-8675 , Japan.
Abstract:
The total syntheses of C-mavacurine-type indole alkaloids, (±)-pleiocarpamine, (±)-normavacurine, and (±)- C-mavacurine, were accomplished. The key step in the syntheses was the cyclization between the metal carbenoid at C16 and the N1 position in a Corynanthe-type compound that was equipped with a diazo function. For this cyclization, the N4 modification of the substrate using an amine-borane complex was indispensable to fix the molecular conformation.
Related Concept Videos
Total Voids in Concrete
Total Internal Reflection Fluorescence Microscopy
Static, Stagnation, Dynamic and Total Pressure
Attenuated Total Reflectance (ATR) Infrared Spectroscopy: Overview
The ATR process begins by directing a beam...
PCR
DNA Replication
Replication in Prokaryotes
DNA replication...

