Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jan 26, 2026

Measuring Local Anaphylaxis in Mice
07:49

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

20.0K

Idiopathic anaphylaxis.

Maria Beatrice Bilò1, Matteo Martini2, Chiara Tontini2

  • 1Allergy Unit, Internal Medicine, Department of Clinical and Molecular Sciences, Marche Polytechnic University, Ancona, Italy.

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
|April 20, 2019
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Understanding the experiences of South Asian adults' management of food allergy.

The journal of allergy and clinical immunology. Global·2026
Same author

Allergen Immunotherapy for the Treatment of Eosinophilic Esophagitis. An EAACI Task Force Systematic Review.

Clinical and translational allergy·2026
Same author

Predicting cross reactivity between the fire ant venom allergen Sol i 3 and the antigen 5 from vespid venoms based on molecular modeling computing.

Journal of immunotoxicology·2026
Same author

Safety of Venom Immunotherapy in Pregnancy: A Multicentre Study.

Allergy·2026
Same author

'Not All Swellings Are Angioedema' - An Overview And Systematic Approach For Acute Medical Physicians.

Acute medicine·2026
Same author

Trace Elements in Allergy: Narrative Review.

Allergy·2026

Idiopathic anaphylaxis (IA) is diagnosed when no cause is found, presenting like other anaphylaxis but potentially responding to steroids. Long-term management involves medication and an epinephrine autoinjector for a generally favorable prognosis.

Area of Science:

  • Immunology
  • Allergy and Clinical Immunology

Background:

  • Idiopathic anaphylaxis (IA) is a diagnosis of exclusion with unknown incidence and prevalence.
  • IA symptoms are acute, similar to other anaphylaxis forms, with potential mast cell activation indicated by elevated histamine and tryptase.
  • The exact pathophysiology remains unclear, but an IgE-mediated pathway is suspected.

Purpose of the Study:

  • To review the current understanding of idiopathic anaphylaxis (IA).
  • To discuss differential diagnoses, pathophysiology, and management strategies for IA.
  • To highlight the generally favorable prognosis of IA with appropriate care.

Main Methods:

  • Literature review of idiopathic anaphylaxis (IA).
  • Analysis of clinical manifestations, diagnostic challenges, and treatment approaches.
Keywords:
anaphylaxisangio-oedemadrug allergyfood allergymast cellsvenom and insect allergy

More Related Videos

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation
04:34

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation

Published on: September 14, 2018

26.5K
Refined Murine Model of Idiopathic Pulmonary Fibrosis
07:51

Refined Murine Model of Idiopathic Pulmonary Fibrosis

Published on: June 17, 2025

964

Related Experiment Videos

Last Updated: Jan 26, 2026

Measuring Local Anaphylaxis in Mice
07:49

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

20.0K
Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation
04:34

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation

Published on: September 14, 2018

26.5K
Refined Murine Model of Idiopathic Pulmonary Fibrosis
07:51

Refined Murine Model of Idiopathic Pulmonary Fibrosis

Published on: June 17, 2025

964
  • Comparison of IA with other forms of anaphylaxis and allergy mimics.

    • Main Results:

    • IA shares clinical features with other anaphylaxis types, with mast cell activation markers observed.
    • Corticosteroids show potential in reducing IA episode frequency and severity.
    • Differential diagnoses are extensive, including specific allergies, exercise-induced anaphylaxis, and conditions mimicking anaphylaxis.

    Conclusions:

    • IA management is individualized, involving H1/H2 blockers, leukotriene antagonists, and oral corticosteroids.
    • Patients require an epinephrine autoinjector and a self-management plan.
    • IA generally has a favorable prognosis with proper treatment and education; persistent symptoms warrant re-evaluation of the diagnosis.