Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

5.5K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
5.5K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

27.3K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
27.3K
Adult Stem Cells01:33

Adult Stem Cells

33.4K
Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
33.4K
Embryonic Stem Cells00:58

Embryonic Stem Cells

32.1K
Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
32.1K
Embryonic Stem Cells00:57

Embryonic Stem Cells

4.8K
Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
4.8K
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

4.5K
A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
4.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical outcomes and survival benefits of craniotomy in breast cancer patients with brain metastases: Focusing on candidate selection and early mortality.

Brain & spine·2026
Same author

From plastics to pathology: The neurodegenerative impact of Bisphenol-A on Alzheimer's disease.

Ageing research reviews·2026
Same author

Immunomodulatory Effects of Bifidobacterium bifidum BGN4 in Cyclophosphamide-induced Immunosuppressed Mice via Activation of NK Cells and Macrophages.

Probiotics and antimicrobial proteins·2026
Same author

Clade Differentiation of <i>Candida auris</i> (<i>Candidozyma auris</i>) Clinical Isolates from Korean Hospitals Using Multilocus Sequence Typing and Sequence-Based Identification.

Annals of laboratory medicine·2026
Same author

Metabotropic glutamate receptor 5 expression associates with pain and inflammatory pathways in interstitial cystitis.

Scientific reports·2026
Same author

Targeting DDR1 with novel synthesized antagonists delays cellular aging and enhances wound healing in mesenchymal stem cells.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026

Related Experiment Video

Updated: Jan 26, 2026

Derivation of Hematopoietic Stem Cells from Murine Embryonic Stem Cells
22:06

Derivation of Hematopoietic Stem Cells from Murine Embryonic Stem Cells

Published on: February 25, 2007

14.0K

Production of Mesenchymal Stem Cells Through Stem Cell Reprogramming.

Ahmed Abdal Dayem1, Soo Bin Lee, Kyeongseok Kim

  • 1Department of Stem Cell & Regenerative Biotechnology, Incurable Disease Animal Model and Stem Cell Institute (IDASI), Konkuk University, Gwangjin-gu, Seoul 05029, Korea. ahmed_morsy86@yahoo.com.

International Journal of Molecular Sciences
|April 21, 2019
PubMed
Summary

Pluripotent stem cell-derived mesenchymal stem cells (PSCs-MSCs) offer a promising alternative to tissue-derived MSCs. These PSC-MSCs exhibit superior proliferation and therapeutic potential, overcoming limitations of traditional MSC sources.

Keywords:
differentiation methodsin vitro and in vivo therapeutic efficaciesmesenchymal stem cells (MSCs)pluripotent stem cells (PSCs)pluripotent stem cells-derived mesenchymal stem cells (PSC-MSCs)tissue-derived mesenchymal stem cells

More Related Videos

The Production of Pluripotent Stem Cells from Mouse Amniotic Fluid Cells Using a Transposon System
08:24

The Production of Pluripotent Stem Cells from Mouse Amniotic Fluid Cells Using a Transposon System

Published on: February 28, 2017

7.4K
RNA-based Reprogramming of Human Primary Fibroblasts into Induced Pluripotent Stem Cells
11:38

RNA-based Reprogramming of Human Primary Fibroblasts into Induced Pluripotent Stem Cells

Published on: November 26, 2018

11.0K

Related Experiment Videos

Last Updated: Jan 26, 2026

Derivation of Hematopoietic Stem Cells from Murine Embryonic Stem Cells
22:06

Derivation of Hematopoietic Stem Cells from Murine Embryonic Stem Cells

Published on: February 25, 2007

14.0K
The Production of Pluripotent Stem Cells from Mouse Amniotic Fluid Cells Using a Transposon System
08:24

The Production of Pluripotent Stem Cells from Mouse Amniotic Fluid Cells Using a Transposon System

Published on: February 28, 2017

7.4K
RNA-based Reprogramming of Human Primary Fibroblasts into Induced Pluripotent Stem Cells
11:38

RNA-based Reprogramming of Human Primary Fibroblasts into Induced Pluripotent Stem Cells

Published on: November 26, 2018

11.0K

Area of Science:

  • Regenerative Medicine
  • Stem Cell Biology
  • Cell Therapy

Background:

  • Mesenchymal stem cells (MSCs) show therapeutic potential but face challenges like limited sources and variable quality.
  • Tissue-derived MSCs suffer from senescence and loss of potency with continuous passaging.
  • Pluripotent stem cells (PSCs) offer an alternative source for generating high-quality MSCs.

Purpose of the Study:

  • To review current protocols for deriving MSCs from PSCs (PSC-MSCs).
  • To evaluate the in vitro and in vivo therapeutic efficacy of PSC-MSCs.
  • To highlight advancements and inspire future differentiation methods for PSC-MSCs.

Main Methods:

  • Review of existing literature on PSC-MSC differentiation protocols.
  • Analysis of studies reporting in vitro characterization of PSC-MSCs.
  • Examination of in vivo preclinical and clinical data on PSC-MSC therapeutic applications.

Main Results:

  • PSC-MSCs demonstrate enhanced proliferation capacity compared to tissue-derived MSCs.
  • PSC-MSCs exhibit potent immunomodulatory activities.
  • PSC-MSCs show promising results in various in vivo therapeutic models.

Conclusions:

  • PSC-MSCs represent a superior cell source for regenerative medicine, overcoming limitations of traditional MSCs.
  • Further optimization of differentiation protocols is crucial for widespread clinical translation of PSC-MSCs.
  • PSC-MSCs hold significant potential for advancing cell-based therapies.