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Updated: Jan 26, 2026

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Crystallizing Membrane Proteins for Structure Determination using Lipidic Mesophases
Published on: November 21, 2010
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Outcomes after Epiretinal Membrane Surgery with or Without Internal Limiting Membrane Peeling
Josef Guber1,2, Ioana Pereni3, Hendrik P N Scholl4
1Eye Clinic, Cantonal Hospital St. Gallen, St. Gallen, Switzerland. josef.guber@kssg.ch.
Ophthalmology and Therapy
|April 21, 2019
Summary
Adding internal limiting membrane peel during epiretinal membrane surgery did not change persistent cystoid macular edema rates. Both surgical approaches improved visual acuity and reduced macular thickness similarly.
Area of Science:
- Ophthalmology
- Retinal Surgery
- Macular Edema
Background:
- Persistent postoperative cystoid macular edema (pCME) is a potential complication after epiretinal membrane (ERM) surgery.
- The role of internal limiting membrane (ILM) peeling in pCME incidence is debated.
Purpose of the Study:
- To compare the incidence of pCME in patients undergoing ERM peel alone versus ERM peel with ILM peel.
- To evaluate secondary outcomes including central macular thickness (CMT) and visual acuity.
Main Methods:
- Retrospective analysis of 98 patients undergoing pars plana vitrectomy.
- Patients were divided into two groups: ERM peel only (36 patients) and ERM with ILM peel (62 patients).
- Ophthalmological examinations, including BCVA and OCT, were performed pre-operatively and at 3 weeks and 3 months post-operatively.
Main Results:
- No statistically significant difference in pCME incidence between the ERM only group (22.2%) and the ERM/ILM peel group (12.9%).
- Significant decrease in CMT and significant increase in BCVA observed in both groups post-surgery.
- No significant differences in CMT or BCVA changes between the two treatment groups.
Conclusions:
- ERM peel with or without ILM peel yields similar outcomes regarding pCME incidence.
- Both surgical techniques effectively reduce CMT and improve BCVA postoperatively.
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