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Updated: Jan 26, 2026
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A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites
Published on: August 8, 2014
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Do Third Molars Contribute to Systemic Inflammation? Results From a Population-Based Study From Northeast Germany
Stefan Kindler1, Maria Mksoud2, Birte Holtfreter3
1Chief Resident, Department of Oral and Maxillofacial Surgery/Plastic Surgery, University Medicine Greifswald, Greifswald, Germany.
Summary
Third molars do not appear to increase systemic inflammation markers. However, erupted third molars were linked to lower levels of key peptide hormones like leptin and angiopoietin-2.
Area of Science:
- Oral health and systemic inflammation research.
- Endocrinology and metabolic health studies.
Background:
- Third molars (wisdom teeth) are often implicated in systemic inflammation.
- Understanding the systemic impact of third molars is crucial for patient care.
Purpose of the Study:
- To investigate the association between erupted/impacted third molars and systemic inflammation markers.
- To examine the relationship between third molars and serum levels of inflammatory parameters and peptide hormones.
Main Methods:
- Analysis of data from 2,151 participants in the Study of Health in Pomerania.
- Assessment of third molars using magnetic resonance imaging (MRI).
- Linear regression models adjusted for various demographic and health factors.
Main Results:
- No association found between third molars and systemic inflammation markers (hs-CRP, WBC, fibrinogen).
- Erupted third molars correlated with lower serum levels of leptin and angiopoietin-2.
- Impacted third molars showed no significant associations with inflammation or peptide hormones.
Conclusions:
- Third molars are not substantiated as a cause of increased systemic inflammation.
- Dental practitioners should exercise caution when considering third molar removal solely for systemic inflammation.
- Erupted third molars may be associated with beneficial lower levels of certain peptide hormones.
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