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Updated: Jan 26, 2026

Electrophoretic Delivery of γ-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice
Published on: May 16, 2019
Expanded Bed Adsorption of γ-Aminobutyric Acid from E. coli broth by CS16GC and IRC747 Resins
Trinath Pathapati1, Dennis N Rütze1, Piet den Boer1
1Xendo B.V. Bio Science Park, Schipholweg 73-75 2316 ZL Leiden The Netherlands.
Abstract:
Expanded-bed adsorption (EBA) is an efficient downstream technology that enhances the techno-economic potential of bio-based industries. However, application of EBA for bulk biochemicals requires the use of industrial resins. Therefore, two cation exchangers, namely, gel-type CS16GC and porous IRC747, were tested to purify γ-aminobutyric acid (GABA) from unclarified E. coli fermentation broth. Experiments compared the impact of gel-type and macroporous resin properties on the EBA process performance. As an outcome, the gel-type resin exhibited higher GABA binding capacity of compared to that of macroporous resin. This was due to improved hydrodynamics and uniform flow distribution in the case of gel-type resin. Further, CS16GC effectively removed ≥ 99 % of impurities and achieved ≥ 97 % GABA yield.
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