Functions of promyelocytic leukaemia zinc finger (Plzf) in male germline stem cell development and differentiation

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Daguia Zambe John Clotaire1, Yudong Wei2, Xiuwei Yu2

  • 1College of Veterinary Medicine, Shaanxi Centre of Stem Cells Engineering and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China; and Laboratoire des sciences Agronomiques et Biologiques pour le Développement (LASBAD), Faculty of Science, University of Bangui, Bangui, 999111, Central Africa.

Reproduction, Fertility, and Development
|April 23, 2019
PubMed

Insights

Promyelocytic leukaemia zinc finger (Plzf) is crucial for male germline stem cell (mGSC) development and spermatogenesis. This review highlights Plzf

Area of Science:

  • Reproductive Biology
  • Developmental Biology
  • Molecular Endocrinology

Background:

  • Promyelocytic leukaemia zinc finger (Plzf), also known as ZBTB16 or ZFP145, is a key transcription factor in male germline stem cells (mGSCs).
  • Plzf plays a vital role in the development, differentiation, and maintenance of various stem cell populations, particularly in mammalian testis development and spermatogenesis.

Purpose of the Study:

  • To review the current literature on the significance of Plzf in maintaining and regulating self-renewal and differentiation of mGSCs.
  • To focus specifically on the role of Plzf in goat mGSCs, examining its expression specificity, functions, and regulatory mechanisms.

Main Methods:

  • Literature review of existing studies on Plzf function in mGSCs.
  • Analysis of evidence regarding Plzf expression patterns during germ cell development.
  • Examination of microRNA-mediated regulatory mechanisms controlling Plzf expression.

Main Results:

  • Plzf is essential for the self-renewal and differentiation of mGSCs.
  • Plzf expression is specific to certain germ cell developmental stages.
  • MicroRNAs play a role in regulating Plzf expression in mGSCs.

Conclusions:

  • Plzf is a critical regulator of mGSC function and spermatogenesis.
  • Understanding Plzf's role and its regulation by microRNAs is important for reproductive biology research, particularly in species like goats.

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