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A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
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A Study on the Pressure-Lowering Effect of the Multilayer Stent
Xiufeng Jin1, Shangdong Xu1, Zengsheng Chen2
1Department of Cardiology Ward 1, Beijing Anzhen Hospital of Capital Medical University, Beijing, China.
Annals of Vascular Surgery
|April 23, 2019
Summary
Multilayer stents slightly reduced pressure in aortic aneurysm models. However, the pressure decrease was minimal, suggesting limited effectiveness in preventing aneurysm expansion compared to traditional covered stents.
Area of Science:
- Biomedical Engineering
- Fluid Dynamics
- Vascular Surgery
Background:
- Investigating hemodynamic changes in aortic aneurysms is crucial for effective treatment.
- Multilayer stents are a novel approach for treating aortic aneurysms.
Purpose of the Study:
- To analyze the fluid dynamic properties of multilayer stents in an aortic aneurysm model.
- To evaluate the effectiveness of multilayer stents in reducing pressure within aneurysms.
Main Methods:
- A glass aneurysm model was used on a circular flow pressure test platform.
- Pressure measurements were taken in the aneurysm model with and without a multilayer stent.
- Fluid dynamic analysis was performed using an experimental liquid.
Main Results:
- Mean pressure in the aneurysm model decreased after multilayer stent placement.
- A mean pressure reduction of 0.59 Kpa at the middle part and 0.71 Kpa at the distal neck was observed.
- The observed pressure reduction was deemed potentially insufficient for significant aneurysm expansion prevention.
Conclusions:
- Multilayer stents can reduce pressure within aortic aneurysm models.
- The pressure-lowering effect may not be substantial enough for effective abdominal aortic aneurysm treatment.
- Further comparison with traditional covered stents is warranted to determine optimal treatment strategies.
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