Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

What is Conservation Biology?01:57

What is Conservation Biology?

24.0K
Conservation biology is a scientific field that focuses on the preservation of biodiversity in order to protect ecosystems while meeting the needs of the human population. Humans require properly functioning ecosystems to maintain our supply of natural resources, including food, medicines, and building materials.
24.0K
Biological Effects of Radiation02:59

Biological Effects of Radiation

17.7K
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
17.7K
Protein Dynamics in Living Cells01:19

Protein Dynamics in Living Cells

2.6K
Different fluorescence-based techniques are used to study the protein dynamics in living cells. These techniques include FRAP, FRET, and PET.
Fluorescent recovery after photobleaching (FRAP) is a fluorescent-protein-based detection technique used to quantify protein movement rates within the cell. This method exposes a small portion of the cell to an intense laser beam. The laser beam causes permanent photobleaching of the fluorophore-tagged proteins in the exposed region. As the bleached...
2.6K
Dynamic Equilibrium02:20

Dynamic Equilibrium

62.1K
A reversible chemical reaction represents a chemical process that proceeds in both forward (left to right) and reverse (right to left) directions. When the rates of the forward and reverse reactions are equal, the concentrations of the reactant and product species remain constant over time and the system is at equilibrium. A special double arrow is used to emphasize the reversible nature of the reaction. The relative concentrations of reactants and products in equilibrium systems vary greatly;...
62.1K
Synthetic Biology02:55

Synthetic Biology

5.5K
Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
5.5K
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

548
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
548

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sirt1 transgene delivery improves diabetes-impaired wound healing.

Bioactive materials·2026
Same author

Affinity Enhancement in Discrete Multivalent MegaMolecules.

Chembiochem : a European journal of chemical biology·2026
Same author

Controlled Assembly of Vesicle-Based Superstructures Using Megamolecules.

ACS applied materials & interfaces·2026
Same author

33 Unresolved Questions in Nanoscience and Nanotechnology.

ACS nano·2025
Same author

The Role of MegaMolecule Antibody Structure in Internalization and Signaling.

ACS chemical biology·2025
Same author

The emerging era of structural nanomedicine.

Nature reviews bioengineering·2025
Same journal

Poiseuille and extensional flow small-angle scattering for developing structure-rheology relationships in soft matter systems.

Current opinion in colloid & interface science·2024
Same journal

Advances in Nitric Oxide-Releasing Hydrogels for Biomedical Applications.

Current opinion in colloid & interface science·2023
Same journal

Engineering Innovative Interfaces for Point-of-Care Diagnostics.

Current opinion in colloid & interface science·2023
Same journal

Virology from the perspective of theoretical colloid and interface science.

Current opinion in colloid & interface science·2022
Same journal

Harnessing the Full Potential of Extracellular Vesicles as Drug Carriers.

Current opinion in colloid & interface science·2022
Same journal

Editorial Overview: Hot Topic: COVID-19: Colloid and Interface Aspects of COVID-19.

Current opinion in colloid & interface science·2021
See all related articles

Related Experiment Video

Updated: Jan 26, 2026

Probing C84-embedded Si Substrate Using Scanning Probe Microscopy and Molecular Dynamics
13:58

Probing C84-embedded Si Substrate Using Scanning Probe Microscopy and Molecular Dynamics

Published on: September 28, 2016

12.2K

Dynamic Substrates for Cell Biology.

Pradeep Bugga1, Milan Mrksich1

  • 1Department of Chemistry, Northwestern University, Evanston, Illinois, 60208 United States.

Current Opinion in Colloid & Interface Science
|April 24, 2019
PubMed
Summary
This summary is machine-generated.

Researchers are developing dynamic substrates to better study cell-matrix interactions. These advanced biointerfaces allow real-time modulation of ligand activity, enhancing our understanding of cellular behavior in biological systems.

More Related Videos

Quantitative Analysis of Cell Edge Dynamics during Cell Spreading
10:54

Quantitative Analysis of Cell Edge Dynamics during Cell Spreading

Published on: May 22, 2021

5.9K
Live Cell Imaging of F-actin Dynamics via Fluorescent Speckle Microscopy FSM
19:16

Live Cell Imaging of F-actin Dynamics via Fluorescent Speckle Microscopy FSM

Published on: August 5, 2009

16.5K

Related Experiment Videos

Last Updated: Jan 26, 2026

Probing C84-embedded Si Substrate Using Scanning Probe Microscopy and Molecular Dynamics
13:58

Probing C84-embedded Si Substrate Using Scanning Probe Microscopy and Molecular Dynamics

Published on: September 28, 2016

12.2K
Quantitative Analysis of Cell Edge Dynamics during Cell Spreading
10:54

Quantitative Analysis of Cell Edge Dynamics during Cell Spreading

Published on: May 22, 2021

5.9K
Live Cell Imaging of F-actin Dynamics via Fluorescent Speckle Microscopy FSM
19:16

Live Cell Imaging of F-actin Dynamics via Fluorescent Speckle Microscopy FSM

Published on: August 5, 2009

16.5K

Area of Science:

  • Biointerface Science
  • Cellular Biology
  • Materials Science

Background:

  • Studying cell-extracellular matrix interactions is challenging due to their complexity.
  • Interface science has enabled the creation of models for biological matrices with immobilized ligands.
  • A growing area of research involves dynamic substrates that modulate ligand activity in real-time.

Purpose of the Study:

  • To review strategies for manipulating ligand activity on dynamic substrates.
  • To highlight recent advancements in dynamic substrate technology.
  • To discuss the applications enabled by these dynamic biointerfaces.

Main Methods:

  • Review of existing literature on dynamic substrates and ligand modulation.
  • Analysis of recent research in biointerface science.
  • Discussion of experimental approaches for creating and utilizing dynamic substrates.

Main Results:

  • Various strategies exist to dynamically control ligand activity on substrates.
  • Recent work has significantly advanced the development of these dynamic systems.
  • Dynamic substrates have enabled novel applications in cell biology and bioengineering.

Conclusions:

  • Dynamic substrates represent a significant advancement in studying cell-matrix interactions.
  • These substrates offer powerful tools for both basic research and applied biointerface technologies.
  • The field of dynamic biointerfaces is expected to continue expanding with important future applications.