Comparison between Roche Integra 400 plus and Abbott Architect ci8200 in Alanine aminotransferase assay
Somiya Lamrabat1,2, Amina Lyagoubi1,2, Ouardia Bouayadi1,2
1Central Laboratory of Mohammed VI University Hospital of Oujda City, Morocco.
Practical Laboratory Medicine
|April 24, 2019
Summary
The Abbott Architect ci8200 and Roche Integra 400 plus show high agreement for alanine aminotransferase (ALT) testing. This comparative study confirms reliable ALT assay results between these two diagnostic systems.
Area of Science:
- Clinical Chemistry
- Diagnostic Assays
- Biomarker Analysis
Background:
- Alanine aminotransferase (ALT) is a key biomarker for liver function.
- Accurate ALT measurement is crucial for diagnosing and monitoring liver diseases.
- Evaluating different diagnostic platforms ensures reliable clinical laboratory results.
Purpose of the Study:
- To compare the performance of ALT assays on the Abbott Architect ci8200 and Roche Integra 400 plus systems.
- To assess the concordance and agreement between these two widely used diagnostic analyzers.
Main Methods:
- Prospective analysis of ALT levels in 200 hospitalized patients.
- Utilized spectrophotometric methods on both Abbott Architect ci8200 and Roche Integra 400 plus analyzers.
- Statistical evaluation included Bland-Altman analysis and Passing-Bablok regression.
Main Results:
- A high concordance was observed between the two ALT assays, with a Passing-Bablok correlation coefficient (r²) of 0.999.
- The mean bias between the Architect and Integra methods was approximately 1.1 IU/L.
- The observed differences in ALT measurements ranged from -1.4 to 3.6 IU/L.
Conclusions:
- The Abbott Architect ci8200 and Roche Integra 400 plus demonstrate excellent agreement for ALT testing.
- Both systems provide reliable and comparable ALT assay results, supporting their use in clinical settings.
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