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Updated: Jan 25, 2026

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
Published on: January 17, 2020
Chiral phosphoric acid-catalyzed enantioselective construction of structurally diverse benzothiazolopyrimidines
Lucie Jarrige1, Danijel Glavač1,2, Guillaume Levitre1
1Institut de Chimie des Substances Naturelles , CNRS UPR 2301 , Université Paris-Sud , Université Paris-Saclay , 1, Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex , France .
Abstract:
A highly efficient catalytic enantioselective [4+2] cycloaddition was developed between 2-benzothiazolimines and enecarbamates. A wide range of benzothiazolopyrimidines bearing three contiguous stereogenic centers was obtained in high to excellent yields and with excellent diastereo- and enantioselectivities (d.r. > 98 : 2 and up to >99% ee). Furthermore, this chiral phosphoric acid-catalyzed strategy was scalable and enabled access to a new class of optically pure Lewis base isothiourea derivatives.
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