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Updated: Jan 25, 2026

Detection of Protein S-Acylation using Acyl-Resin Assisted Capture
Published on: April 10, 2020
Cobalt-catalyzed cyclization with the introduction of cyano, acyl and aminoalkyl groups
Hiroto Hori1, Shigeru Arai, Atsushi Nishida
1Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 2608675, Japan. araisgr@chiba-u.jp.
Abstract:
An efficient synthesis of carbo- and heterocycles using C[double bond, length as m-dash]C, C[double bond, length as m-dash]O and C[double bond, length as m-dash]N bonds under cobalt catalysis is described. The substituents on olefins are key for controlling the regio- and chemoselectivity in the initial hydrogen atom transfer step and quaternary carbons are efficiently constructed under mild conditions. Cyclopropane cleavage and tandem cyclization give highly functionalized bicyclic skeletons in a single operation.
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