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Choroidal thickness in thyroid-associated orbitopathy.

Frank H P Lai1,2, Tiara W U Iao1, Danny S C Ng1,3

  • 1Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong.

Clinical & Experimental Ophthalmology
|April 30, 2019
PubMed
Summary
This summary is machine-generated.

Thyroid-associated orbitopathy (TAO) patients exhibit increased choroidal thickness (CT) in macular regions compared to healthy individuals. Thinner subfoveal CT in TAO correlates with worse exophthalmos and vision, suggesting EDI-OCT

Keywords:
choroidoptical coherence tomographythicknessthyroid-associated orbitopathy

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Area of Science:

  • Ophthalmology
  • Endocrinology
  • Medical Imaging

Background:

  • Thyroid-associated orbitopathy (TAO) is an autoimmune condition affecting the eye socket.
  • Choroidal thickness (CT) changes may be associated with TAO pathogenesis and severity.
  • Understanding CT variations can aid in TAO diagnosis and management.

Purpose of the Study:

  • To investigate and compare choroidal thickness (CT) between patients with thyroid-associated orbitopathy (TAO) and healthy controls.
  • To identify correlations between CT and clinical/ocular parameters in TAO patients.

Main Methods:

  • Prospective cross-sectional study involving 52 TAO patients and 26 healthy subjects.
  • Enhanced-depth imaging optical coherence tomography (EDI-OCT) used for CT measurements at macular and peripapillary regions.
  • Multivariate linear regression analyzed associations between subfoveal CT and systemic/ocular variables in TAO.

Main Results:

  • TAO patients showed significantly increased CT in subfoveal and surrounding macular regions compared to controls.
  • No significant differences in CT were observed in the peripapillary regions between groups.
  • Thinner subfoveal CT in TAO eyes correlated with worsening exophthalmos, poorer visual acuity, older age, and longer axial length.

Conclusions:

  • Patients with TAO demonstrate thickened choroids in macular areas, but not peripapillary regions, relative to healthy individuals.
  • Reduced subfoveal choroidal thickness is linked to more severe exophthalmos and diminished visual acuity in TAO.
  • EDI-OCT is a valuable tool for monitoring choroidal vascular alterations in TAO and its complications.