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Pediatric Ototoxicity: Current Trends and Management.

Brian J Fligor1,2,3

  • 1Tobias and Battite, Inc., Boston, Massachusetts.

Seminars in Hearing
|May 1, 2019
PubMed
Summary

Ototoxicity from cancer treatments can impact survivors

Area of Science:

  • Ototoxicity research
  • Pediatric audiology
  • Clinical oncology

Background:

  • Cancer treatments, while lifesaving, can cause ototoxicity, impacting survivors' quality of life.
  • Healthcare providers and families are increasingly concerned about the long-term effects of medication-induced hearing loss and tinnitus.
  • Accurate ototoxicity grading scales and monitoring are crucial for managing hearing loss in patients undergoing treatment.

Purpose of the Study:

  • To highlight the importance of sensitive ototoxicity grading scales for non-audiologists.
  • To emphasize the role of audiological monitoring in early detection and intervention of hearing loss.
  • To underscore the need for pediatric-specific protocols for managing medication-induced hearing loss and tinnitus.

Main Methods:

Keywords:
aminoglycosidescisplatin chemotherapyototoxicity

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  • Review of current ototoxicity grading scales and audiological monitoring protocols.
  • Analysis of the communication gap between audiologists and other healthcare providers (e.g., oncologists).
  • Discussion of the implications for pediatric patient management and habilitation.

    • Main Results:

    • Existing grading scales aim to simplify audiological data for oncologists to guide chemotherapy decisions.
    • Effective monitoring protocols reduce the delay between hearing loss onset and diagnosis/intervention.
    • Pediatric protocols facilitate timely habilitation and management of permanent hearing loss and tinnitus.

    Conclusions:

    • Sensitive ototoxicity grading scales and robust audiological monitoring are essential for managing hearing loss in patients receiving ototoxic therapies.
    • These tools improve clinical decision-making, enable early intervention, and ensure appropriate care for pediatric survivors.
    • Standardized protocols are vital for addressing the significant quality-of-life impacts of ototoxicity.