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Updated: Jan 25, 2026

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Published on: May 7, 2013
Pressurized Metered Dose Inhaler Technology: Manufacturing
Ernest Vallorz1, Poonam Sheth2, Paul Myrdal3
1College of Pharmacy, Department of Pharmacology and Toxicology, University of Arizona, 1703 E. Mabel St., Skaggs Building Rm 437, Tucson, Arizona, 85721, USA. vallorz@pharmacy.arizona.edu.
Abstract:
While first introduced in the 1950s, pressurized metered dose inhalers (pMDIs) remain as a first line treatment of pulmonary conditions. With expanding applications of pMDIs beyond asthma and chronic obstructive pulmonary disease (COPD), the development of therapies utilizing the pMDI platform will undoubtedly continue. Recent guidances and the introduction of quality by design initiatives further emphasize the requirement of formulators to understand the relationships between product attributes and production strategies and their impact on product performance. This review summarizes common manufacturing processes of pMDIs across multiple stages of the development cycle, from academia to commercial production, and provides insight as to the benefits and limitations of each process in regard to formulation type.
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