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Pressurized Metered Dose Inhaler Technology: Manufacturing.

Ernest Vallorz1, Poonam Sheth2, Paul Myrdal3

  • 1College of Pharmacy, Department of Pharmacology and Toxicology, University of Arizona, 1703 E. Mabel St., Skaggs Building Rm 437, Tucson, Arizona, 85721, USA. vallorz@pharmacy.arizona.edu.

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Summary
This summary is machine-generated.

Pressurized metered dose inhalers (pMDIs) are crucial for pulmonary conditions. This review details pMDI manufacturing processes, aiding formulators in understanding product development and performance.

Keywords:
cold fillingcritical quality attribute (CQA)manufacturingpressure fillingpressurized metered dose inhaler (pMDI)

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Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Pulmonary Medicine

Background:

  • Pressurized metered dose inhalers (pMDIs) have been a primary treatment for pulmonary conditions since the 1950s.
  • Their application is expanding beyond asthma and chronic obstructive pulmonary disease (COPD).
  • Quality by design initiatives necessitate a deeper understanding of pMDI product attributes and manufacturing impacts.

Purpose of the Study:

  • To review common manufacturing processes for pMDIs.
  • To analyze these processes across different development stages, from academic research to commercial production.
  • To offer insights into the advantages and disadvantages of each method concerning various formulation types.

Main Methods:

  • Literature review of pMDI manufacturing processes.
  • Analysis of process benefits and limitations.
  • Categorization of methods based on development stage and formulation type.

Main Results:

  • Common pMDI manufacturing processes are identified and described.
  • Benefits and limitations of each process are discussed in relation to formulation type.
  • Insights are provided for optimizing pMDI production from early development to commercialization.

Conclusions:

  • Understanding pMDI manufacturing processes is vital for effective drug development.
  • The choice of manufacturing process significantly impacts pMDI performance.
  • This review serves as a guide for formulators navigating pMDI development and production.