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Updated: Jan 25, 2026
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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
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Personality traits in migraine and medication-overuse headache: A comparative study.
Louise S Mose1,2,3, Susanne S Pedersen4,5, Rigmor H Jensen6
1Department of Neurology, Hospital of South West Jutland, Esbjerg, Denmark.
Acta Neurologica Scandinavica
|May 1, 2019
Summary
Personality differences exist between medication-overuse headache (MOH) and migraine patients, particularly in females. MOH females scored lower on extraversion, openness, and conscientiousness, suggesting potential for personalized headache treatment.
Area of Science:
- Neurology
- Psychology
- Behavioral Science
Background:
- Medication-overuse headache (MOH) is a biobehavioral disorder requiring integrated treatment approaches.
- Personality traits may influence headache diagnoses and could be leveraged for personalized treatment strategies.
Purpose of the Study:
- To determine if personality traits differ between patients with migraine and MOH.
- To compare the personality profiles of migraine and MOH patients against a Danish normative sample.
Main Methods:
- The NEO-Five-Factor Inventory assessed personality traits (neuroticism, extraversion, openness, agreeableness, conscientiousness).
- An age-matched cohort of episodic migraine (n=94) and MOH (n=94) patients was studied.
- Multivariate regression and sex-stratified comparisons were conducted against a normative sample (n=1032).
Main Results:
- MOH females exhibited significantly lower scores in extraversion, openness, and conscientiousness compared to female migraineurs.
- No significant personality differences were observed between male migraine and MOH patients.
- Both headache groups displayed lower extraversion scores than the normative sample; MOH patients also showed lower conscientiousness.
Conclusions:
- Distinct personality traits were identified between migraine and MOH patients, especially in females.
- MOH females presented as more introverted and less socially oriented.
- These findings may inform personalized treatment approaches for headache disorders in clinical practice.
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