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Tuberculous meningitis: A neglected tropical disease?
1Department of Neurology, NYU Langone Health, New York, NY.
Neurology. Clinical Practice
|May 2, 2019
Summary
Tuberculous meningitis (TBM) remains a neglected and lethal form of tuberculosis despite global efforts. Urgent research is needed for TBM incidence, diagnostics, and effective treatments.
Area of Science:
- Infectious Diseases
- Neurology
- Public Health
Background:
- Tuberculosis (TB) is a leading infectious cause of death globally.
- Tuberculous meningitis (TBM), a severe TB manifestation, is under-researched and lacks guidelines.
- Despite significant investment in pulmonary TB, TBM remains neglected.
Purpose of the Study:
- To highlight the urgent need for research in tuberculous meningitis.
- To address the lack of evidence-based guidelines for TBM management.
- To call for advancements in TBM diagnostics and therapeutics.
Main Methods:
- This study is a review and call for research, not an experimental study.
- It synthesizes existing knowledge on the burden and neglect of TBM.
- It identifies critical research priorities in TBM.
Main Results:
- TBM is the most lethal form of tuberculosis.
- There is a significant paucity of research and guidelines for TBM.
- Reliable global incidence data for TBM is lacking.
Conclusions:
- Tuberculous meningitis requires urgent research attention.
- Development of advanced CSF diagnostic technologies for TBM is crucial.
- Evaluation of drug regimens with enhanced CNS penetration is necessary for TBM treatment.
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