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Updated: Jan 25, 2026

Peptide-based Identification of Functional Motifs and their Binding Partners
Published on: June 30, 2013
Variational principle for scale-free network motifs
Clara Stegehuis1, Remco van der Hofstad2, Johan S H van Leeuwaarden2
1Department of Mathematics and Computer Science, Eindhoven University of Technology, Eindhoven, Netherlands. c.stegehuis@tue.nl.
Abstract:
For scale-free networks with degrees following a power law with an exponent τ ∈ (2, 3), the structures of motifs (small subgraphs) are not yet well understood. We introduce a method designed to identify the dominant structure of any given motif as the solution of an optimization problem. The unique optimizer describes the degrees of the vertices that together span the most likely motif, resulting in explicit asymptotic formulas for the motif count and its fluctuations. We then classify all motifs into two categories: motifs with small and large fluctuations.
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