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Glucose sensing by absorption spectroscopy using lensed optical fibers
Applied Optics
|May 3, 2019
Summary
We developed flexible, lensed fibers for near-infrared transmission spectroscopy, enabling remote sensing. This innovation shows promise for applications like in vivo continuous glucose monitoring.
Area of Science:
- Optical spectroscopy
- Biomedical sensing
- Fiber optics
Background:
- Traditional transmission spectroscopy probes are bulky, limiting their use in remote or internal body applications.
- Developing miniaturized and flexible spectroscopic tools is crucial for advanced biomedical monitoring.
Purpose of the Study:
- To fabricate and characterize lensed fibers for near-infrared transmission spectroscopy.
- To assess the feasibility of using these fibers for remote sensing applications, particularly in biological samples.
Main Methods:
- Fabrication of lensed optical fibers designed for transmission spectroscopy.
- Eigenmode simulations and coupling efficiency measurements to optimize the spectroscopic setup.
- Demonstration of sensing capabilities using aqueous glucose solutions.
Main Results:
- Successfully fabricated and characterized lensed fibers suitable for near-infrared transmission spectroscopy.
- Achieved a mean absolute percentage error of 4.3% when calibrating for aqueous glucose concentrations from 80 to 500 mM.
- Demonstrated the potential for flexible, remote spectroscopic sensing.
Conclusions:
- Lensed fibers offer a flexible alternative to bulky probes for transmission spectroscopy.
- This technology could enable new possibilities for in vivo continuous monitoring, such as for glucose levels.
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