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Salvage open partial horizontal laryngectomy after failed radiotherapy: A multicentric study.
Andy Bertolin1, Marco Lionello1, Marco Ghizzo1
1Otorhinolaryngology Service, Vittorio Veneto Hospital, Treviso, Italy.
The Laryngoscope
|May 3, 2019
Summary
Open partial horizontal laryngectomy (OPHL) offers successful salvage for laryngeal squamous cell carcinoma (LSCC) after radiotherapy failure. This approach provides good oncologic outcomes and survival rates in selected patients.
Area of Science:
- Otolaryngology
- Surgical Oncology
- Head and Neck Cancer Research
Background:
- Laryngeal squamous cell carcinoma (LSCC) recurrence after radiotherapy (RT) presents a significant clinical challenge.
- Salvage surgery is a critical option for patients who fail initial RT for LSCC.
Purpose of the Study:
- To evaluate the multi-institutional experience with open partial horizontal laryngectomy (OPHL) as a salvage procedure for LSCC post-RT failure.
- To analyze prognostic factors influencing oncologic outcomes in these patients.
- To compare findings with existing literature on salvage laryngectomy.
Main Methods:
- Retrospective multicenter analysis of surgical oncological outcomes.
- Review of clinical charts for 70 patients with recurrent LSCC after primary RT failure who underwent salvage OPHL.
Main Results:
- Disease-free status achieved in 65% of patients at last follow-up.
- Overall survival was 75%, with disease-specific survival at 87%.
- Local control rate was 87%, and laryngectomy-free survival was 91%.
Conclusions:
- Open partial horizontal laryngectomy (OPHL) is a viable and effective salvage option for selected patients with LSCC after radiotherapy failure.
- Careful patient selection based on established criteria is crucial for successful conservation laryngeal surgery outcomes.
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