OCT Angiography Imaging in Serpiginous Choroidopathy

Area of Science:

• Ophthalmology
• Medical Imaging
• Retinal Diseases

Background:

• Serpiginous choroidopathy (SC) is an inflammatory condition affecting the choroid and retinal pigment epithelium.
• Understanding the vascular changes in SC is crucial for diagnosis and management.

Purpose of the Study:

• To document optical coherence tomography angiography (OCTA) findings in active and inactive serpiginous choroidopathy (SC).
• To describe OCTA changes in response to treatment for SC.

Main Methods:

• A retrospective case series of 3 patients (6 eyes) with SC was conducted.
• Multimodal imaging, including OCTA, was utilized.
• Pre- and post-treatment OCTA images were compared in one treated eye.

Main Results:

• OCTA demonstrated apparent absence of the choriocapillaris in active SC, with outer retinal and RPE thickening.
• Following treatment, partial reappearance of the choriocapillaris was observed, particularly at lesion margins.
• In inactive SC, the choriocapillaris, RPE, and outer retina were absent.

Conclusions:

• OCTA suggests choriocapillaris absence in both active and inactive SC phases.
• Partial reestablishment of the choriocapillaris occurs after treatment.
• OCTA aids in evaluating choroidal involvement in SC, though pathogenesis remains unclear.