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Updated: Jan 25, 2026

Integrated Photoacoustic Ophthalmoscopy and Spectral-domain Optical Coherence Tomography
Published on: January 15, 2013
In Vivo Adaptive Optics Ophthalmoscopy Correlated with Histopathologic Results in Cancer-Associated Retinopathy
Zoë R Williams1, Ethan A Rossi2, David A DiLoreto3
1Flaum Eye Institute, University of Rochester Medical Center, Rochester, New York.
Purpose:
To demonstrate the validity of adaptive optics scanning laser ophthalmoscopy (AOSLO) imaging of the retina in human disease based on clinicopathologic correlation in a patient with cancer-associated retinopathy (CAR).
Design:
Case report.
Participant:
Sixty-four-year-old man with CAR.
Methods:
Fundus photography, electroretinography, visual field testing, fundus autofluorescent imaging, spectral-domain OCT scans, AOSLO, and histopathologic analysis were performed.
Main Outcome Measure:
Comparison of AOSLO with histopathologic results.
Results:
Changes in photoreceptor morphologic features were correlated highly between AOSLO and histopathologic results.
Conclusions:
We present a unique case where a patient with a rare and fatal disease, CAR, underwent AOSLO imaging during the course of the disease, and then shortly thereafter, postmortem histopathologic analysis of the eyes was carried out. This is the first report of use of AOSLO to elucidate further the retinal changes that occur in CAR and the first study to demonstrate correlation of AOSLO with histopathologic results in any human disease.
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