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Updated: Jan 25, 2026

Preparation of a Corannulene-functionalized Hexahelicene by CopperI-catalyzed Alkyne-azide Cycloaddition of Nonplanar Polyaromatic Units
Published on: September 18, 2016
Solvent-slaved protein motions accompany proton coupled electron transfer reactions catalysed by copper nitrite
Tobias M Hedison1, Derren J Heyes1, Muralidharan Shanmugam1
1The Manchester Institute of Biotechnology, University of Manchester, Manchester, M1 7DN, UK. nigel.scrutton@manchester.ac.uk.
Abstract:
Through the use of time-resolved pH-jump spectroscopy, we demonstrate how proton transfer is coupled to inter-copper electron transfer in a copper nitrite reductase (CuNiR). Combined use of electron paramagnetic resonance spectroscopy with solvent viscosity- and pressure-dependence pH-jump stopped-flow spectroscopy is used to show that solvent-slaved protein motions are linked to this proton coupled electron transfer step in CuNiR.
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