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Updated: Jan 25, 2026

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FDG PET/MRI Findings Pointing Toward a Gayet-Wernicke Encephalopathy

Laura Rozenblum, Marie-Odile Habert, Nadya Pyatigorskaya1

  • 1Department of Functional and Diagnostic Neuroradiology, Groupe Hospitalier Pitié-Salpêtrière-Charles Foix, Assistance Publique-Hôpitaux de Paris, Sorbonne Université.

Clinical Nuclear Medicine
|May 7, 2019
PubMed

Insights

This study highlights how F-FDG PET/MRI can diagnose Gayet-Wernicke encephalopathy by revealing decreased metabolism in the mammillary bodies (MBs). Thiamine (vitamin B1) deficiency correction improved symptoms, confirming the diagnosis.

Area of Science:

  • Neurology
  • Radiology
  • Nuclear Medicine

Background:

  • Gayet-Wernicke encephalopathy (GWE) is a serious neurological condition often linked to thiamine deficiency.
  • Diagnosis can be challenging, especially with inconclusive standard MRI scans.
  • Early detection is crucial for effective treatment and preventing irreversible neurological damage.

Observation:

  • A patient with memory impairment and a history of alcohol use disorder presented with inconclusive MRI findings.
  • F-FDG PET/MRI was performed to investigate the cause of memory loss.
  • The scan revealed significant metabolic reduction in the hippocampus and mammillary bodies (MBs).

Findings:

  • PET/MRI analysis showed severe reduction in MB metabolism and atrophy, alongside signal alterations.
  • These findings were highly suggestive of Gayet-Wernicke encephalopathy, despite previous inconclusive MRIs.
  • Metabolic patterns did not indicate a neurodegenerative disease.

Implications:

  • Hybrid PET/MRI is effective for evaluating small brain structures like MBs in GWE.
  • This imaging modality aids in diagnosing GWE when conventional MRI is insufficient.
  • Prompt diagnosis and thiamine (vitamin B1) repletion can lead to symptom improvement in GWE patients.

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