Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Structural Protein Function01:56

Structural Protein Function

29.9K
Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity.  In bones and teeth, it mineralizes to...
29.9K
Structural Protein Function01:56

Structural Protein Function

3.2K
3.2K
Fruit Development, Structure, and Function01:58

Fruit Development, Structure, and Function

25.1K
Fruits form from a mature flower ovary. As seeds develop from the ovules contained within, the ovary wall undergoes a series of complex changes to form fruit. In some fruits, such as soybeans, the ovary wall dries; in other fruits, such as grapes, it remains fleshy. In some cases, organs other than the ovary contribute to fruit formation; such fruits are called accessory fruits.
25.1K
Structure and Function of Erythrocytes01:29

Structure and Function of Erythrocytes

5.4K
There are between 4.2 and 6 million erythrocytes, also known as red blood cells, in every microliter of blood. These cells are small, flattened biconcave discs with centers that are depressed.
The erythrocyte plasma membrane is associated with proteins such as spectrin, which forms a flexible cytoplasmic meshwork. This meshwork allows erythrocytes to twist, turn, become cup-shaped, and regain their biconcave shape as they pass through narrow capillaries. Additionally, erythrocytes can form...
5.4K
Structure and Function of Platelets01:18

Structure and Function of Platelets

3.2K
The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
3.2K
Predicting Molecular Geometry02:27

Predicting Molecular Geometry

45.6K
VSEPR Theory for Determination of Electron Pair Geometries
45.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Catalytic enantioselective access to N(III)-stereogenic aziridines <i>via</i> chiral brønsted acid-catalyzed N-Cl bond formation.

Chemical communications (Cambridge, England)·2026
Same author

Exercise dose and multidimensional motor function in young people with Down syndrome: a Bayesian network dose-response meta-analysis.

Pediatric research·2026
Same author

Remote evaluation of rice nitrogen utilization efficiency using chlorophyll-related spectral indices derived from unmanned aerial vehicle imagery.

Frontiers in plant science·2026
Same author

[Research Progress of CAR-T Cell Therapy in Autoimmune Diseases --Review].

Zhongguo shi yan xue ye xue za zhi·2026
Same author

Retraction notice to "microRNA-107 functions as a candidate tumor suppressor gene in renal clear cell carcinoma involving multiple genes" [Urologic Oncology: Seminars and Original Investigations 33 (2015) 205.e1-205.e11].

Urologic oncology·2026
Same author

Partial splenic embolization bridging Wiskott-Aldrich syndrome: Managing frequent bleeding before curative therapy.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology·2026

Related Experiment Video

Updated: Jan 25, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

69.7K

Prediction of IER5 structure and function using a bioinformatics approach.

Qiang Xiong1, Xiaoyan Jiang1, Xiaodan Liu2

  • 1National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, P.R. China.

Molecular Medicine Reports
|May 7, 2019
PubMed
Summary

Immediate-early response gene 5 (IER5) is crucial for cell cycle regulation. Bioinformatics analysis revealed its promoter methylation sites and predicted its protein structure, modifications, and nuclear localization, aiding functional understanding.

More Related Videos

RNA Secondary Structure Prediction Using High-throughput SHAPE
13:42

RNA Secondary Structure Prediction Using High-throughput SHAPE

Published on: May 31, 2013

32.2K
Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
09:08

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

7.2K

Related Experiment Videos

Last Updated: Jan 25, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

69.7K
RNA Secondary Structure Prediction Using High-throughput SHAPE
13:42

RNA Secondary Structure Prediction Using High-throughput SHAPE

Published on: May 31, 2013

32.2K
Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
09:08

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

7.2K

Area of Science:

  • Molecular Biology
  • Bioinformatics
  • Genetics

Background:

  • Immediate-early response gene 5 (IER5) plays a role in cell cycle regulation.
  • Understanding IER5's molecular characteristics is essential for elucidating its function.

Purpose of the Study:

  • To determine promoter methylation sites and Gene Ontology (GO) annotations for IER5.
  • To predict the physical, chemical, and structural properties of the IER5 protein using bioinformatics.

Main Methods:

  • Bioinformatic analysis of the IER5 gene promoter region.
  • Prediction of IER5 protein properties including hydrophobicity, post-translational modifications, subcellular localization, and structural elements.
  • Gene Ontology (GO) enrichment analysis.

Main Results:

  • Identification of a CpG island and methylated sites near the IER5 promoter.
  • GO analysis indicated IER5's involvement in ion and protein binding, primarily in metabolic processes.
  • IER5 predicted as an unstable, hydrophilic protein (327 amino acids) with a pI of 4.91, featuring 18 O-glycosylation and 22 phosphorylation sites.
  • Predicted nuclear localization and dominant alpha-helix secondary structure.

Conclusions:

  • Bioinformatic predictions provide insights into IER5's structure and function.
  • Further experimental validation is necessary to confirm the predicted characteristics of IER5.