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Related Experiment Video

Updated: Jan 25, 2026

Postoperative Ileus Murine Model

Postoperative Ileus Murine Model

Published on: July 12, 2024

Postoperative Ileus.

Cristina R Harnsberger¹, Justin A Maykel¹, Karim Alavi¹

¹Division of Colon and Rectal Surgery, University of Massachusetts, Boston, Massachusetts.

Clinics in Colon and Rectal Surgery

|May 8, 2019

Summary

This summary is machine-generated.

Postoperative ileus (POI) is a frequent complication after colorectal surgery. Minimally invasive approaches and multimodal pain management show promise in reducing its occurrence and duration.

Keywords:

colorectal complication paralytic ileus postoperative ileus

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Area of Science:

Gastroenterology and Surgical Outcomes

Background:

Postoperative ileus (POI) affects 10-30% of patients after colorectal surgery, increasing morbidity and hospital stay.
POI is a temporary, nonmechanical inhibition of gastrointestinal motility post-surgery, hindering oral intake.
Identified risk factors include advanced age, ASA scores 3-4, open surgery, long operative duration, and blood loss.

Purpose of the Study:

To review risk factors and mitigation strategies for postoperative ileus following colorectal surgery.
To evaluate the effectiveness of various interventions in reducing POI incidence and duration.

Main Methods:

Literature review of studies investigating risk factors and treatments for POI.
Analysis of evidence for minimally invasive surgery, multimodal pain regimens, chewing gum, alvimopan, and enhanced recovery protocols.

Main Results:

Minimally invasive approaches and multimodal pain management are associated with reduced POI development.
Interventions like chewing gum, alvimopan, and ERAS protocols may benefit selected patients, but data remain inconclusive.
Risk factors include age, ASA score, open approach, operative duration, bowel handling, and fluid management.

Conclusions:

Minimally invasive surgery and multimodal pain management are key strategies to mitigate POI.
Further research is needed to confirm the efficacy of specific interventions for POI in diverse patient groups.
Understanding and managing risk factors are crucial for improving outcomes after colorectal surgery.