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Two-photon axotomy and time-lapse confocal imaging in live zebrafish embryos
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Maternal body mass index affects embryo morphokinetics: a time-lapse study
Alessandro Bartolacci1, Jose Buratini1,2, Clarissa Moutier1
1Biogenesi, Reproductive Medicine Centre, Monza, Italy.
Journal of Assisted Reproduction and Genetics
|May 8, 2019
Summary
Maternal body mass index (BMI) impacts human embryo development. Obesity and overweight are linked to slower embryo development, as shown by time-lapse technology, but not static morphology.
Area of Science:
- Reproductive biology
- Embryology
- In vitro fertilization (IVF)
Background:
- Body Mass Index (BMI) is a measure of body fat.
- Assisted Reproductive Technology (ART) success can be influenced by various maternal factors.
- Time-lapse technology offers detailed insights into embryo development.
Purpose of the Study:
- To investigate the effect of maternal Body Mass Index (BMI) on human embryo morphokinetics.
- To compare embryo development parameters between different BMI categories using time-lapse imaging.
Main Methods:
- Retrospective analysis of ART cycles using time-lapse technology.
- Categorization of patients into underweight, normal weight, overweight, and obese groups based on BMI.
- Evaluation of morphokinetic parameters (e.g., time to blastomere stages) and static morphology.
Main Results:
- Obesity and overweight were associated with delayed times to reach key blastomere stages (t5 and t8) compared to normal weight.
- No significant differences in embryo morphology or pregnancy rates were observed across BMI groups.
- Underweight women had a higher miscarriage rate compared to normal weight women.
Conclusions:
- Time-lapse technology reveals that maternal BMI influences embryo development, unlike traditional static morphology assessments.
- Maternal obesity and overweight are correlated with a slower pace of embryo development.
- BMI is a significant factor to consider in ART, impacting both embryo development and pregnancy outcomes.
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