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04:41
Plaquing of Herpes Simplex Viruses
Published on: November 5, 2021
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T-cell pseudolymphoma in recurrent herpes simplex virus infection
Christina Mitteldorf1, Eva Geissinger2, Marc Pleimes3
1Department of Dermatology, Venereology and Allergology, University Medical Center, Göttingen, Germany.
Journal of Cutaneous Pathology
|May 8, 2019
Summary
Diagnosing herpes simplex virus (HSV)-associated pseudolymphoma can be challenging. This study identifies subtle histomorphologic and clinical features to aid in accurate diagnosis, differentiating it from cutaneous lymphoma.
Area of Science:
- Dermatopathology
- Virology
- Immunohistochemistry
Background:
- Herpes virus infections without typical signs are difficult to diagnose histologically.
- Misdiagnosis as cutaneous lymphoma is a concern in such cases.
Purpose of the Study:
- To identify key histomorphologic and clinical features of herpes simplex virus (HSV)-associated pseudolymphoma.
- To improve diagnostic accuracy and differentiate from cutaneous lymphoma.
Main Methods:
- Retrospective analysis of five patients with HSV-associated pseudolymphoma.
- Investigation of clinical, histomorphologic, and immunophenotypic features.
Main Results:
- Histology showed perivascular infiltrate, epidermotropism, atypia, plasma cells, and junctional zone lymphocyte lining (CD8+ predominance).
- Clinical presentation included patchy erythema, erosions, crusts, and a history of blisters, pain, or itching.
- Papillary edema was observed in four of five cases.
Conclusions:
- Subtle but consistent histomorphologic criteria, combined with clinical presentation, aid in diagnosing HSV-associated pseudolymphoma.
- Distinguishing HSV-associated pseudolymphoma from cutaneous lymphoma is crucial for appropriate patient management.
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