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Related Concept Videos

Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

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Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
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Protein Complex Assembly02:41

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Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
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Assembly of Complex Microtubule Structures01:32

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Complex microtubule structures are present in resting cells and in dividing cells. In resting cells, they are responsible for maintaining the cellular architecture, tracks for intracellular transport, positioning of organelles, assembly of cilia and flagella. They mediate the bipolar spindle assembly for chromosomal segregation and positioning of the cell division plate in dividing cells. The formation of microtubule complex structures depends on the cell type, cell stage, and cell function.
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Fruit Development, Structure, and Function01:58

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Fruits form from a mature flower ovary. As seeds develop from the ovules contained within, the ovary wall undergoes a series of complex changes to form fruit. In some fruits, such as soybeans, the ovary wall dries; in other fruits, such as grapes, it remains fleshy. In some cases, organs other than the ovary contribute to fruit formation; such fruits are called accessory fruits.
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Formation of Complex Ions

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A type of Lewis acid-base chemistry involves the formation of a complex ion (or a coordination complex) comprising a central atom, typically a transition metal cation, surrounded by ions or molecules called ligands. These ligands can be neutral molecules like H2O or NH3, or ions such as CN− or OH−. Often, the ligands act as Lewis bases, donating a pair of electrons to the central atom. These types of Lewis acid-base reactions are examples of a broad subdiscipline called coordination...
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Crystal Field Theory - Octahedral Complexes02:58

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Crystal Field Theory
To explain the observed behavior of transition metal complexes (such as colors), a model involving electrostatic interactions between the electrons from the ligands and the electrons in the unhybridized d orbitals of the central metal atom has been developed. This electrostatic model is crystal field theory (CFT). It helps to understand, interpret, and predict the colors, magnetic behavior, and some structures of coordination compounds of transition metals.
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Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous β2-Microglobulin
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Polycomb Repressive Complex 2: Modulator Development for Functional Regulation of a Multiprotein Complex by Using

Yasuaki Tokodai1, Fumika Yakushiji1,2

  • 1Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo, 060-0812, Japan.

Chembiochem : a European Journal of Chemical Biology
|May 8, 2019
PubMed
Summary
This summary is machine-generated.

This study explores regulating the polycomb repressive complex 2 (PRC2) using chemical modulators. Understanding PRC2 structure and interactions can lead to new therapeutic strategies for complex biological events.

Keywords:
epigeneticspolycomb repressive complex 2protein modificationsprotein-protein interactionsstructure elucidation

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Epigenetics

Background:

  • Protein complexes are crucial for cellular functions but challenging to regulate functionally.
  • The polycomb repressive complex 2 (PRC2) is a key epigenetic regulator involved in complex biological events.
  • Limited information on the overall structure of protein complexes hinders targeted functional regulation.

Purpose of the Study:

  • To introduce the potential for functional regulation of the polycomb repressive complex 2 (PRC2) via chemical modulators.
  • To describe the functional regulatory mechanisms of PRC2.
  • To discuss the development of novel chemical modulators for PRC2 based on structural insights.

Main Methods:

  • Utilizing structural analyses to gather protein interaction information.
  • Investigating functional regulatory mechanisms of PRC2.
  • Analyzing structural insights into the PRC2 complex and its related interactions.

Main Results:

  • Protein interaction information derived from structural analyses provides insights into PRC2 functional regulation.
  • Structural insights reveal possibilities for developing novel chemical modulators targeting PRC2.
  • The study highlights the potential for targeted modulation of PRC2 activity.

Conclusions:

  • Functional regulation of protein complexes like PRC2 is achievable through chemical modulators.
  • Structural biology approaches are key to understanding and targeting complex biological machinery.
  • Developing chemical modulators for PRC2 opens new avenues for therapeutic interventions in diseases involving epigenetic dysregulation.