Related Experiment Video
Updated: Jan 25, 2026

The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes
Published on: April 10, 2015
Potential anticancer applications of the novel naringin-based ruthenium (II) complex
John Phillip Garcia1, Buddolla Anantha Lakshmi1, Sanghyo Kim1
1Department of Bio Nanotechnology, Gachon University, San 65, Bokjeong-Dong, Sujeong-Gu, Seongnam-Si, Gyeonggi-Do 461-701 Republic of Korea.
Abstract:
Ruthenium seems to be a promising alternative to platinum because of the wide range of oxidation states it has and its ability to form complexes with bioactive ligands. In this study, naringin, a naturally occurring flavonoid, was used to synthesize a novel ruthenium complex with potential anticancer activity. The characterization of the synthesized complex was done by UV-Vis spectroscopy, FTIR and NMR studies. In addition, the complex was tested against Human A549 cell lines to determine the anticancer effect, and against human dermal fibroblasts (HDFa) to find any underlying toxicity. Further, the morphological changes of the cancer cells can be determined by using bio-atomic force microscopy. Results showed that the synthesized complex was able to induce anticancer effects against A549 with minimal impact to HDFa. In this study, we investigated the anticancer properties of naringin-ruthenium (II) complex using live- and dead-cell staining assay, MTT, Trypan blue, and lactate dehydrogenase assay. Further, morphological changes were observed in the A549 cells using Bio-AFM. The Bio-AFM results have proven the better cytotoxic behavior of naringin-ruthenium (II) complex. The cell viability results also provided the anticancer efficacy of the complex.
More Related Videos
Related Concept Videos
Formation of Complex Ions
Potential Energy
Chemical bonds that form attractive forces between atoms also contain potential energy, called chemical energy. When a chemical reaction...
Protein Complex Assembly
Many viruses self-assemble into a fully functional unit using the infected host cell to...
Protein Complexes with Interchangeable Parts
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order...
Standard Electrode Potentials
Cell Potential and Free Energy
Thermodynamics is the branch of physics dealing with the relationship between heat and other forms of energy. In an electrochemical cell, chemical energy is converted into electrical energy.
Thus, a link can be predicted between cell potential, free energy change, and the equilibrium constant for the reaction. Cell potential can also be measured as the oxidant or the reducing strength, and similar acid-base strength measures are reflected in equilibrium...

