Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Phase Diagrams02:39

Phase Diagrams

49.9K
A phase diagram combines plots of pressure versus temperature for the liquid-gas, solid-liquid, and solid-gas phase-transition equilibria of a substance. These diagrams indicate the physical states that exist under specific conditions of pressure and temperature and also provide the pressure dependence of the phase-transition temperatures (melting points, sublimation points, boiling points). Regions or areas labeled solid, liquid, and gas represent single phases, while lines or curves represent...
49.9K
Phase Transitions02:31

Phase Transitions

22.8K
Whether solid, liquid, or gas, a substance's state depends on the order and arrangement of its particles (atoms, molecules, or ions). Particles in the solid pack closely together, generally in a pattern. The particles vibrate about their fixed positions but do not move or squeeze past their neighbors. In liquids, although the particles are closely spaced, they are randomly arranged. The position of the particles are not fixed—that is, they are free to move past their neighbors to...
22.8K
Inductance: Single-Phase And Three-Phase Line01:28

Inductance: Single-Phase And Three-Phase Line

615
Understanding the inductance of transmission lines is crucial for efficient design and operation in electrical power systems. This discussion delves into the inductance characteristics of single-phase two-wire and three-phase three-wire transmission lines with equal phase spacing.
Single-Phase Two-Wire Line:
A single-phase line consists of two solid cylindrical conductors, denoted as x and y. Each conductor carries phasor currents ix and iy, respectively. Given that the sum of these currents is...
615
Capacitance: Single-Phase And Three-Phase Line01:25

Capacitance: Single-Phase And Three-Phase Line

592
In electrical power systems, understanding the capacitance of transmission lines is fundamental for efficient operation.
Single-Phase Lines
Consider a single-phase, two-wire transmission line with equal phase spacing energized by a voltage source. One conductor carries a uniform positive charge, while the other carries an equal negative charge. The capacitance C of the line can be derived from the voltage V between the conductors. For a one-meter section of the line, the capacitance is given...
592
Phase Changes01:19

Phase Changes

5.2K
Phase transitions play an important theoretical and practical role in the study of heat flow. In melting or fusion, a solid turns into a liquid; the opposite process is freezing. In evaporation, a liquid turns into a gas; the opposite process is condensation.
A substance melts or freezes at a temperature called its melting point and boils or condenses at its boiling point. These temperatures depend on pressure. High pressure favors the denser form of the substance, so typically, high pressure...
5.2K
Phase-lead and Phase-lag Controllers01:22

Phase-lead and Phase-lag Controllers

541
Understanding the working function of different types of controllers can be illustrated with practical analogies, such as adjusting a stereo's volume equalizer. Cranking up the bass involves a phase-lead controller, which functions as a high-pass filter, while increasing the treble uses a phase-lag controller, which acts as a low-pass filter. PD controllers, similar to high-pass filters, enhance the system's response to high-frequency components. PI controllers, akin to low-pass...
541

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Global genetic interaction network of a human cell maps conserved principles and informs functional interpretation of gene co-essentiality profiles.

Cell·2026
Same author

Structural basis for TORC2 activation.

Molecular cell·2026
Same author

Structure and function of the yeast amino acid-sensing SEAC-EGOC supercomplex.

Nature structural & molecular biology·2026
Same author

Limited proteolysis-coupled mass spectrometry captures proteome-wide protein structural alterations and biomolecular condensation in living cells.

Molecular systems biology·2026
Same author

A dynamic feedback loop between retrograde sterol transport and TORC2 controls adaptation of the plasma membrane to stress.

The EMBO journal·2025
Same author

TOR signaling on membranes.

FEBS letters·2025
Same journal

Insulin resistance and type 2 diabetes as allostatic responses to chronic nutrient excess.

Cell metabolism·2026
Same journal

Microbiota and immunotherapy: The birth of a new paradigm?

Cell metabolism·2026
Same journal

Glycerol activates tissue-nonspecific alkaline phosphatase for temperature and bone homeostasis.

Cell metabolism·2026
Same journal

Jack-of-a-new-trade: Itaconate targets the PPP/G6PD to control lung cancer.

Cell metabolism·2026
Same journal

A liver phosphatase reprograms gut stem cells to drive hyperglycemia.

Cell metabolism·2026
Same journal

GLP-1 and MASH: When weight loss isn't the whole story.

Cell metabolism·2026
See all related articles

Related Experiment Video

Updated: Jan 25, 2026

Shaping the Amplitude and Phase of Laser Beams by Using a Phase-only Spatial Light Modulator
08:39

Shaping the Amplitude and Phase of Laser Beams by Using a Phase-only Spatial Light Modulator

Published on: January 28, 2019

10.4K

TOR Signaling Is Going through a Phase.

Manoel Prouteau1, Robbie Loewith2

  • 1Department of Molecular Biology, University of Geneva, 30 Quai Ernest-Ansermet, CH1211 Geneva, Switzerland; Institute of Genetics and Genomics of Geneva (iGE3), University of Geneva Medical School (CMU) 1, rue Michel-Servet, CH - 1211 Geneva 4, Switzerland.

Cell Metabolism
|May 9, 2019
PubMed
Summary
This summary is machine-generated.

Yeast Pbp1 protein undergoes reversible oxidation, forming liquid-like condensates. These condensates inhibit TORC1 signaling, promoting autophagy and restoring metabolic balance.

More Related Videos

Determination of the Gas-phase Acidities of Oligopeptides
11:00

Determination of the Gas-phase Acidities of Oligopeptides

Published on: June 24, 2013

11.6K
Cell Co-culture Patterning Using Aqueous Two-phase Systems
10:11

Cell Co-culture Patterning Using Aqueous Two-phase Systems

Published on: March 26, 2013

19.2K

Related Experiment Videos

Last Updated: Jan 25, 2026

Shaping the Amplitude and Phase of Laser Beams by Using a Phase-only Spatial Light Modulator
08:39

Shaping the Amplitude and Phase of Laser Beams by Using a Phase-only Spatial Light Modulator

Published on: January 28, 2019

10.4K
Determination of the Gas-phase Acidities of Oligopeptides
11:00

Determination of the Gas-phase Acidities of Oligopeptides

Published on: June 24, 2013

11.6K
Cell Co-culture Patterning Using Aqueous Two-phase Systems
10:11

Cell Co-culture Patterning Using Aqueous Two-phase Systems

Published on: March 26, 2013

19.2K

Area of Science:

  • Cellular biology
  • Biochemistry
  • Metabolic regulation

Background:

  • Pbp1 is the yeast homolog of ataxin-2.
  • Metabolic redox status influences cellular processes.
  • Autophagy is a key cellular homeostasis mechanism.

Purpose of the Study:

  • To investigate the role of Pbp1 in linking metabolic redox status to cellular signaling.
  • To understand the mechanism by which Pbp1 regulates TORC1 signaling and autophagy.

Main Methods:

  • The study utilized yeast models.
  • Researchers examined the reversible oxidation of methionines in Pbp1.
  • Phase separation of Pbp1 and its effect on TORC1 signaling were analyzed.

Main Results:

  • Reversible oxidation of methionines in Pbp1 was observed.
  • Pbp1 undergoes phase separation into liquid-like condensates.
  • Pbp1 condensates were found to inhibit target of rapamycin complex 1 (TORC1) signaling.

Conclusions:

  • Pbp1 acts as a redox sensor, coupling metabolic state to Pbp1 phase separation.
  • Pbp1 condensate formation inhibits TORC1 signaling, inducing autophagy.
  • This pathway restores metabolic homeostasis in yeast.