Related Experiment Video
Updated: Jan 25, 2026

Determination of the Photoisomerization Quantum Yield of a Hydrazone Photoswitch
Published on: February 7, 2022
Synthetic Photoswitchable Neurotransmitters Based on Bridged Azobenzenes
Gisela Cabré1, Aida Garrido-Charles2, Àngels González-Lafont1,3
1Departament de Química , Universitat Autònoma de Barcelona (UAB) , Cerdanyola del Vallès 08193 , Spain.
Abstract:
Photoswitchable neurotransmitters of ionotropic kainate receptors were synthesized by tethering a glutamate moiety to disubstituted C2-bridged azobenzenes, which were prepared through a novel methodology that allows access to diazocines with higher yields and versatility. Because of the singular properties of these photochromes, photoisomerizable compounds were obtained with larger thermal stability for their inert cis isomer than for their biologically activity trans state. This enabled selective neuronal firing upon irradiation without background activity in the dark.
More Related Videos
12:48Construction of Cell-based Neurotransmitter Fluorescent Engineered Reporters CNiFERs for Optical Detection of Neurotransmitters In Vivo
Published on: May 12, 2016
16:11Protocols for Implementing an Escherichia coli Based TX-TL Cell-Free Expression System for Synthetic Biology
Published on: September 16, 2013
Related Concept Videos
Neurotransmitters
Neurotransmitters
Design Example: Strain Gauge Bridge or Wheatstone Bridge
Bridge rectifier
Operationally, the bridge rectifier allows current flow through two of its diodes during each...
Wheatstone Bridge
Thus, for accurate resistance measurements, a...
Classification of Neurotransmitters