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Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction
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Galectin-3 Levels and Outcomes After Myocardial Infarction: A Population-Based Study
Rabea Asleh1, Maurice Enriquez-Sarano1, Allan S Jaffe1
1Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota.
Journal of the American College of Cardiology
|May 11, 2019
Summary
Galectin-3 (Gal-3) predicts higher mortality and heart failure (HF) risk after myocardial infarction (MI). Measuring Gal-3 aids in post-MI risk stratification for better patient outcomes.
Area of Science:
- Cardiology
- Biomarkers
- Clinical Research
Background:
- Galectin-3 (Gal-3) is linked to cardiac fibrosis.
- Its prognostic significance following myocardial infarction (MI) remains unclear.
Purpose of the Study:
- To investigate the predictive value of Galectin-3 (Gal-3) in a community-based cohort experiencing incident myocardial infarction (MI).
Main Methods:
- Prospective assembly of a population-based MI cohort (2002-2012).
- Measurement of Galectin-3 (Gal-3) levels at the time of MI.
- Follow-up for heart failure (HF) and mortality.
Main Results:
- Elevated Gal-3 levels were associated with older age and more comorbidities.
- Higher Gal-3 tertiles significantly increased the risk of death (up to 2.4-fold) and HF (up to 2.3-fold) post-MI.
- These associations remained significant after adjusting for clinical factors and were independent of recurrent MI.
Conclusions:
- Galectin-3 (Gal-3) serves as an independent predictor of mortality and heart failure (HF) after myocardial infarction (MI).
- Gal-3 measurement can enhance risk stratification in patients post-MI.
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