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Updated: Jan 25, 2026

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Amplifying and Quantifying HIV-1 RNA in HIV Infected Individuals with Viral Loads Below the Limit of Detection by Standard Clinical Assays
Published on: September 26, 2011
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The Yellow Brick Road towards HIV Eradication.
Asier Saez-Cirion1, Michaela Müller-Trutwin1
1Institut Pasteur, HIV Inflammation and Persistence Unit, 75015 Paris, France.
Trends in Immunology
|May 11, 2019
Summary
A London patient achieved HIV-1 remission for over a year after a stem cell transplant using CCR5-tropic resistant cells. This marks a significant step in understanding potential cures for HIV-1 infection.
Area of Science:
- Virology
- Immunology
- Hematology
Background:
- Human Immunodeficiency Virus type 1 (HIV-1) infection remains a global health challenge.
- Current antiretroviral therapies control viral replication but do not eliminate the virus.
- Achieving sustained remission or a functional cure for HIV-1 is a primary research goal.
Purpose of the Study:
- To report on a second case of sustained HIV-1 remission following a specific type of stem cell transplant.
- To analyze the immunological and virological factors contributing to remission in this patient.
Main Methods:
- The study involved a patient with HIV-1 who underwent a bone marrow stem cell transplant.
- The donor cells were specifically selected for resistance to CCR5-tropic HIV-1 strains.
- Long-term monitoring of viral load and immunological markers was performed.
Main Results:
- The patient achieved remission from HIV-1 infection, maintaining undetectable viral loads for over one year post-transplant.
- The transplanted cells' resistance to CCR5-tropic HIV-1 is a key factor in the observed remission.
- This case corroborates findings from previous similar interventions.
Conclusions:
- Stem cell transplantation from donors with CCR5-delta32 homozygous mutation can lead to sustained HIV-1 remission.
- This approach offers valuable insights into potential curative strategies for HIV-1.
- Further research is needed to optimize and generalize this potentially curative treatment.
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