Related Experiment Video
Updated: Jul 9, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
[Psoriasis and the microbiome]
1Klinik für Dermatologie, UKSH Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Deutschland. mareike.witte@uksh.de.
Background:
Psoriasis is a frequent chronic inflammatory systemic disease. It is associated with changes in the microbiome, which may trigger psoriasis and influence the course of the disease.
Objective:
Current methods for detection and the potential role of the microbiome in the pathogenesis of psoriasis are described.
Material And Methods:
A literature search was conducted using the databases Medline and PubMed as well as a general internet and book research.
Results:
Both skin and gut microbiota are involved in the immunopathogenesis and may substantially modulate psoriasis. Antimicrobial peptides may serve as a link between the microbiome and the immunological mechanisms in psoriasis by regulating the microbiome at interfaces and can trigger psoriasis as antigens. Recent innovative methods, such as 16S rRNA next-generation sequencing significantly facilitate microbiome analysis.
Conclusion:
The analysis of the microbiome in patients with psoriasis before, during and after treatment provides a basis for the identification of potential biomarkers for predicting individual treatment responses and facilitating the decision for a certain treatment.
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Introduction to the Human Microbiota
The Skin Microbiota
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The Oral Microbiota
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Dysbiosis of the Gut Microbiota

