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Updated: Jan 25, 2026
08:22
Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids
Published on: August 11, 2017
16.4K
Effective bioprinting resolution in tissue model fabrication.
Amir K Miri1, Iman Mirzaee2, Shabir Hassan3
1Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA. yszhang@research.bwh.harvard.edu and Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA and Department of Mechanical Engineering, Rowan University, Glassboro, NJ 08028, USA.
Lab on a Chip
|May 14, 2019
Summary
Bioprinting resolution is key for creating accurate micro-tissues in organ-on-a-chip systems. This study analyzes inkjet, extrusion, and light-assisted methods to optimize fabrication for biomimetic tissue engineering.
Area of Science:
- Biomaterials Engineering
- Tissue Engineering
- Biotechnology
Background:
- Advancements in bioprinting enable micro-tissue fabrication for organ-on-a-chip (OOC) platforms.
- Bioprinted micro-tissue architecture fidelity is crucial for mimicking native anatomical features.
Purpose of the Study:
- To compare inkjet, extrusion, and light-assisted bioprinting technologies.
- To analyze factors influencing micro-tissue fabrication resolution for OOC platforms.
- To provide a guideline for optimizing bioprinting resolution for biomimetic tissue construction.
Main Methods:
- Theoretical analysis of bioprinting technologies (inkjet, extrusion, light-assisted).
- Evaluation of key parameters affecting resolution for each method.
- Comparative study of fabrication resolutions for micro-tissue engineering.
Main Results:
- Inkjet bioprinting resolution is dominated by surface contact angle.
- Extrusion bioprinting resolution depends on nozzle speed and bioink viscosity.
- Light-assisted bioprinting resolution is influenced by photocrosslinking and light characteristics.
Conclusions:
- Understanding these parameters is vital for optimizing bioprinting resolution.
- This research aids in developing more accurate biomimetic OOC platforms.
- The findings offer a guideline for improving micro-tissue fabrication in OOC applications.
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