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Vitamin D Status in Egyptian Children With Allergic Rhinitis

Khaled Saad1, Abobakr Abdelmoghny2, Mohamed Diab Aboul-Khair3

  • 1Faculty of Medicine, Department of Pediatrics, 68796Assiut University, Assiut, Egypt.

Ear, Nose, & Throat Journal
|May 16, 2019
PubMed

Insights

Vitamin D deficiency is common in Egyptian children with allergic rhinitis (AR). Lower vitamin D levels correlate with increased AR severity and symptoms.

Area of Science:

  • Pediatric Allergy and Immunology
  • Nutritional Biochemistry
  • Epidemiology

Background:

  • Allergic rhinitis (AR) is a prevalent condition in children.
  • Vitamin D plays a crucial role in immune system regulation.
  • The association between vitamin D status and AR severity requires further investigation, particularly in diverse ethnic cohorts.

Purpose of the Study:

  • To determine serum vitamin D levels in Egyptian children diagnosed with allergic rhinitis.
  • To investigate the relationship between vitamin D status and the severity of allergic rhinitis.
  • To explore correlations between vitamin D levels, clinical symptoms, and immunoglobulin E in pediatric AR.

Main Methods:

  • Cross-sectional study involving 120 children with AR and 100 healthy controls.
  • Measurement of serum 25(OH)D and 1,25(OH)2D levels in all participants.
  • Statistical analysis to compare vitamin D levels and assess associations with AR severity, symptom scores, and total IgE.

Main Results:

  • Children with AR exhibited significantly lower serum calcium, 25(OH)D, and 1,25(OH)2D levels compared to healthy controls.
  • Patients with moderate/severe AR had significantly lower mean 25-OHD3 levels than those with mild AR.
  • Negative correlations were observed between 25(OH)D levels and total nasal symptom score (r = -0.62) and total IgE levels (r = -0.27) in the AR group.

Conclusions:

  • Vitamin D deficiency is prevalent in Egyptian children suffering from allergic rhinitis.
  • Lower vitamin D levels are significantly associated with increased allergic rhinitis severity in this pediatric cohort.
  • Findings suggest a potential role for vitamin D supplementation in managing allergic rhinitis in children.

Keywords:
allergic rhinitischildrenvitamin D

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