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Updated: Jan 24, 2026

Study of the DNA Damage Checkpoint using Xenopus Egg Extracts
Published on: November 5, 2012
[Immunotherapy with immune checkpoint inhibitors and hepatitis]
Nathalie Baudoux1, Grégoire Berthod2, Frank Bally3
1Service d'oncologie, HUG, 1211 Genève 14.
Abstract:
Immunotherapy, with « checkpoint » inhibitors (CPIs), has become an essential therapeutic weapon against cancer. Autoimmune disorders related to overactivation of the immune system are well known side effects. The risk of reactivation of the hepatitis B and C viruses and exacerbation of the hepatitis, known from the introduction of immunosuppressive drugs such as chemotherapy, is poorly documented under immunotherapy. In this article, we discuss the issue of immunotherapy in patients presented with hepatitis using two approaches: the risks of immunotherapy in these situations and the management by disruption of liver tests under immunotherapy.
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