Related Experiment Video
Updated: Jan 24, 2026

Light-driven Enzymatic Decarboxylation
Published on: May 22, 2016
Visible-Light-Driven Chlorotrifluoromethylative and Chlorotrichloromethylative Cyclizations of Enynes
Hong Hou1, Daliang Tang1, Hengxue Li1
1School of Chemistry & Chemical Engineering , Yangzhou University , Yangzhou 225005 , China.
Abstract:
Described herein is a visible-light-driven chlorotrifluoromethylative and chlorotrichloromethylative cyclization reaction to synthesize chlorotrifluoromethylated and chlorotrichloromethylated cyclic compounds. Visible-light photochemistry was utilized to generate trifluoromethyl and trichloromethyl radicals and trigger radical addition/cyclization/chlorination sequences. The use of terminal alkene-derived enynes enables the regioselective and stereoselective synthesis of chlorotrifluoromethylated and chlorotrichloromethylated pyrrolidines, piperidines, and cyclopentanes.
Related Concept Videos
Intramolecular Claisen Condensation of Dicarboxylic Esters: Dieckmann Cyclization
Light as Energy
Photons
A photon is a discrete electromagnetic particle or bundle of energy. Photons are characterized by their frequency, wavelength, and amplitude, similar to the properties of a wave. Waves with higher frequencies transmit more energy and have shorter wavelengths than longer wavelengths that transmit...
The Wave Nature of Light
ATP Driven Pumps I: An Overview
There are four main types of ATP-driven pumps - P-type, V-type, F-type, and ABC transporter. All these pumps are of varying complexities and...
Light Acquisition
Ultraviolet and Visible (UV–Vis) Spectroscopy: Overview

