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[FIBROTIC MARKERS IN INFANTS WITH PYELONEPHRITIS]

N Tokarchuk1, Y Vyzhga1, V Tokarchuk1

  • 1Vinnytsya National Medical University N. Pirogov, Ukraine.

Georgian Medical News
|May 19, 2019
PubMed

Insights

Infants with pyelonephritis and vesicoureteral reflux show elevated levels of monocyte chemoattractant protein-1 (MCP-1) and transforming growth factor beta-1 (TGF-β1). These markers correlate with inflammation and disease severity.

Area of Science:

  • Pediatric Nephrology
  • Immunology
  • Genetics

Background:

  • Pyelonephritis is a serious kidney infection in infants.
  • Vesicoureteral reflux (VUR) is a common risk factor for pyelonephritis.
  • Biomarkers of inflammation and fibrosis are crucial for understanding disease progression.

Purpose of the Study:

  • To estimate serum levels of transforming growth factor beta-1 (TGF-β1) and monocyte chemoattractant protein-1 (MCP-1) in infants with pyelonephritis.
  • To investigate the relationship between these biomarkers and disease activity in pyelonephritis with VUR.
  • To explore the association of TGF-β1 gene polymorphisms with the risk of developing pyelonephritis in infants.

Main Methods:

  • Serum samples were collected from infants diagnosed with pyelonephritis, with and without VUR.
  • Levels of MCP-1 and TGF-β1 were quantified using immunoassay techniques.
  • C-reactive protein (CRP) levels were measured to assess inflammation.
  • Genotyping for TGF-β1 gene polymorphisms (C-509C, T+869T) was performed.

Main Results:

  • Infants with pyelonephritis and VUR exhibited significantly higher serum MCP-1 levels (2.5-fold increase) compared to those with primary pyelonephritis.
  • A strong positive correlation was found between MCP-1 and CRP levels (rxy=0.66, p<0.01) in infants with pyelonephritis and VUR.
  • Serum TGF-β1 levels were markedly elevated (2.8-fold increase) in infants with pyelonephritis and VUR versus primary pyelonephritis.
  • Elevated TGF-β1 levels correlated with increased disease activity.
  • Specific TGF-β1 genotypes (C-509C and T+869T) were associated with a 4.48-fold higher probability of developing pyelonephritis in early childhood.

Conclusions:

  • Pyelonephritis in infants with VUR is characterized by heightened inflammatory activity and elevated levels of MCP-1 and TGF-β1.
  • MCP-1 and TGF-β1 serve as important indicators of disease severity and progression in pediatric pyelonephritis.
  • TGF-β1 gene polymorphisms may influence susceptibility to pyelonephritis in young children.

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